Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is a poor-prognosis cancer type with limited understanding of its molecular etiology. Using 508 ESCC genomes, we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’ outcomes....

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Detalles Bibliográficos
Autores principales: Cui, Yongping, Chen, Hongyan, Xi, Ruibin, Cui, Heyang, Zhao, Yahui, Xu, Enwei, Yan, Ting, Lu, Xiaomei, Huang, Furong, Kong, Pengzhou, Li, Yang, Zhu, Xiaolin, Wang, Jiawei, Zhu, Wenjie, Wang, Jie, Ma, Yanchun, Zhou, Yong, Guo, Shiping, Zhang, Ling, Liu, Yiqian, Wang, Bin, Xi, Yanfeng, Sun, Ruifang, Yu, Xiao, Zhai, Yuanfang, Wang, Fang, Yang, Jian, Yang, Bin, Cheng, Caixia, Liu, Jing, Song, Bin, Li, Hongyi, Wang, Yi, Zhang, Yingchun, Cheng, Xiaolong, Zhan, Qimin, Li, Yanhong, Liu, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608103/
https://www.ncbi.nlm.nih.gov/pubmed/32398863
http://dx.doi.org/10.1038/s41422-020-0333-6

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