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s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand–foot skin reaction that can be reversed by nicotinamide

Hand–foot skin reaction (HFSR), among the most significant adverse effects of sorafenib, has been limiting the clinical benefits of this frontline drug in treating various malignant tumors. The mechanism underlying such toxicity remains poorly understood, hence the absence of effective intervention...

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Detalles Bibliográficos
Autores principales:	Luo, Peihua, Yan, Hao, Chen, Xueqin, Zhang, Ying, Zhao, Ziying, Cao, Ji, Zhu, Yi, Du, Jiangxia, Xu, Zhifei, Zhang, Xiaochen, Zeng, Su, Yang, Bo, Ma, Shenglin, He, Qiaojun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608389/ https://www.ncbi.nlm.nih.gov/pubmed/32296111 http://dx.doi.org/10.1038/s41422-020-0309-6

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