USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity

Cyclic GMP-AMP synthase (cGAS) is an essential sensor of cytosolic DNA and critically mediates innate immune responses and autoimmunity. Modulating the activity and stability of cGAS provides potential strategies for treating viral or autoimmune diseases. Here, we report that ubiquitin-specific prot...

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Detalles Bibliográficos
Autores principales: Zhang, Qiang, Tang, Zhen, An, Ran, Ye, Liya, Zhong, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608407/
https://www.ncbi.nlm.nih.gov/pubmed/32457395
http://dx.doi.org/10.1038/s41422-020-0341-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608407/
https://www.ncbi.nlm.nih.gov/pubmed/32457395
http://dx.doi.org/10.1038/s41422-020-0341-6

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