High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4

Relaxin/insulin-like family peptide receptor 4 (RXFP4) is a class A G protein-coupled receptor (GPCR), and insulin-like peptide 5 (INSL5) is its endogenous ligand. Although the precise physiological role of INSL5/RXFP4 remains elusive, a number of studies have suggested it to be a potential therapeu...

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Detalles Bibliográficos
Autores principales: Lin, Guang-yao, Lin, Lin, Cai, Xiao-qing, Dai, An-tao, Zhu, Yue, Li, Jie, Liu, Qing, Yang, De-hua, Bathgate, Ross A. D., Wang, Ming-wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608467/
https://www.ncbi.nlm.nih.gov/pubmed/32235863
http://dx.doi.org/10.1038/s41401-020-0390-x

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