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Definition and diagnosis of fracture-related infection

Fracture-related infection (FRI) is common and often diagnosed late. Accurate diagnosis is the beginning of effective treatment. Diagnosis can be difficult, particularly when there are no outward signs of infection. The new FRI definition, together with clear protocols for nuclear imaging, microbiol...

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Autores principales: McNally, Martin, Govaert, Geertje, Dudareva, Maria, Morgenstern, Mario, Metsemakers, Willem-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: British Editorial Society of Bone and Joint Surgery 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608516/
https://www.ncbi.nlm.nih.gov/pubmed/33204503
http://dx.doi.org/10.1302/2058-5241.5.190072
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author McNally, Martin
Govaert, Geertje
Dudareva, Maria
Morgenstern, Mario
Metsemakers, Willem-Jan
author_facet McNally, Martin
Govaert, Geertje
Dudareva, Maria
Morgenstern, Mario
Metsemakers, Willem-Jan
author_sort McNally, Martin
collection PubMed
description Fracture-related infection (FRI) is common and often diagnosed late. Accurate diagnosis is the beginning of effective treatment. Diagnosis can be difficult, particularly when there are no outward signs of infection. The new FRI definition, together with clear protocols for nuclear imaging, microbiological culture and histological analysis, should allow much better study design and a clearer understanding of infected fractures. In recent years, there has been a new focus on defining FRI and avoiding non-specific, poorly targeted treatment. Previous studies on FRI have often failed to define infection precisely and so are of limited value. This review highlights the essential principles of making the diagnosis and how clinical signs, serum tests, imaging, microbiology, molecular biology and histology all contribute to the diagnostic pathway. Cite this article: EFORT Open Rev 2020;5:614-619. DOI: 10.1302/2058-5241.5.190072
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spelling pubmed-76085162020-11-16 Definition and diagnosis of fracture-related infection McNally, Martin Govaert, Geertje Dudareva, Maria Morgenstern, Mario Metsemakers, Willem-Jan EFORT Open Rev Instructional Lecture: General Orthopaedics Fracture-related infection (FRI) is common and often diagnosed late. Accurate diagnosis is the beginning of effective treatment. Diagnosis can be difficult, particularly when there are no outward signs of infection. The new FRI definition, together with clear protocols for nuclear imaging, microbiological culture and histological analysis, should allow much better study design and a clearer understanding of infected fractures. In recent years, there has been a new focus on defining FRI and avoiding non-specific, poorly targeted treatment. Previous studies on FRI have often failed to define infection precisely and so are of limited value. This review highlights the essential principles of making the diagnosis and how clinical signs, serum tests, imaging, microbiology, molecular biology and histology all contribute to the diagnostic pathway. Cite this article: EFORT Open Rev 2020;5:614-619. DOI: 10.1302/2058-5241.5.190072 British Editorial Society of Bone and Joint Surgery 2020-10-26 /pmc/articles/PMC7608516/ /pubmed/33204503 http://dx.doi.org/10.1302/2058-5241.5.190072 Text en © 2020 The author(s) https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) licence (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed.
spellingShingle Instructional Lecture: General Orthopaedics
McNally, Martin
Govaert, Geertje
Dudareva, Maria
Morgenstern, Mario
Metsemakers, Willem-Jan
Definition and diagnosis of fracture-related infection
title Definition and diagnosis of fracture-related infection
title_full Definition and diagnosis of fracture-related infection
title_fullStr Definition and diagnosis of fracture-related infection
title_full_unstemmed Definition and diagnosis of fracture-related infection
title_short Definition and diagnosis of fracture-related infection
title_sort definition and diagnosis of fracture-related infection
topic Instructional Lecture: General Orthopaedics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608516/
https://www.ncbi.nlm.nih.gov/pubmed/33204503
http://dx.doi.org/10.1302/2058-5241.5.190072
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