Frontiers in non-union research

Multifactorial aetiology defines non-unions, with a biological and a mechanical distortion of the timeline of bone healing. Research on new advances to increase osteogenesis and promote non-union healing is strongly directed towards new forms of cell products. Basic science and research on non-union...

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Detalles Bibliográficos
Autores principales: Gómez-Barrena, Enrique, Padilla-Eguiluz, Norma G., Rosset, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: British Editorial Society of Bone and Joint Surgery 2020
Materias:
Instructional Lecture: Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608578/
https://www.ncbi.nlm.nih.gov/pubmed/33204499
http://dx.doi.org/10.1302/2058-5241.5.190062
Descripción
Sumario:Multifactorial aetiology defines non-unions, with a biological and a mechanical distortion of the timeline of bone healing. Research on new advances to increase osteogenesis and promote non-union healing is strongly directed towards new forms of cell products. Basic science and research on non-union treatments is needed to compile preclinical data on new treatments. Bone marrow concentration and expanded mesenchymal stromal cells still require extensive clinical research to confirm efficacy in non-union treatment. Solid preclinical studies, precise cell product definition and preparation, and appropriate ethical and regulatory approvals are needed to assess new advanced therapy medicinal products. Cite this article: EFORT Open Rev 2020;5:574-583. DOI: 10.1302/2058-5241.5.190062

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