Frontiers in non-union research

Multifactorial aetiology defines non-unions, with a biological and a mechanical distortion of the timeline of bone healing. Research on new advances to increase osteogenesis and promote non-union healing is strongly directed towards new forms of cell products. Basic science and research on non-union...

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Autores principales: Gómez-Barrena, Enrique, Padilla-Eguiluz, Norma G., Rosset, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: British Editorial Society of Bone and Joint Surgery 2020
Materias:
Instructional Lecture: Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608578/
https://www.ncbi.nlm.nih.gov/pubmed/33204499
http://dx.doi.org/10.1302/2058-5241.5.190062
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author Gómez-Barrena, Enrique
Padilla-Eguiluz, Norma G.
Rosset, Philippe
author_facet Gómez-Barrena, Enrique
Padilla-Eguiluz, Norma G.
Rosset, Philippe
author_sort Gómez-Barrena, Enrique
collection PubMed
description Multifactorial aetiology defines non-unions, with a biological and a mechanical distortion of the timeline of bone healing. Research on new advances to increase osteogenesis and promote non-union healing is strongly directed towards new forms of cell products. Basic science and research on non-union treatments is needed to compile preclinical data on new treatments. Bone marrow concentration and expanded mesenchymal stromal cells still require extensive clinical research to confirm efficacy in non-union treatment. Solid preclinical studies, precise cell product definition and preparation, and appropriate ethical and regulatory approvals are needed to assess new advanced therapy medicinal products. Cite this article: EFORT Open Rev 2020;5:574-583. DOI: 10.1302/2058-5241.5.190062
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spelling pubmed-76085782020-11-16 Frontiers in non-union research Gómez-Barrena, Enrique Padilla-Eguiluz, Norma G. Rosset, Philippe EFORT Open Rev Instructional Lecture: Basic Science Multifactorial aetiology defines non-unions, with a biological and a mechanical distortion of the timeline of bone healing. Research on new advances to increase osteogenesis and promote non-union healing is strongly directed towards new forms of cell products. Basic science and research on non-union treatments is needed to compile preclinical data on new treatments. Bone marrow concentration and expanded mesenchymal stromal cells still require extensive clinical research to confirm efficacy in non-union treatment. Solid preclinical studies, precise cell product definition and preparation, and appropriate ethical and regulatory approvals are needed to assess new advanced therapy medicinal products. Cite this article: EFORT Open Rev 2020;5:574-583. DOI: 10.1302/2058-5241.5.190062 British Editorial Society of Bone and Joint Surgery 2020-10-26 /pmc/articles/PMC7608578/ /pubmed/33204499 http://dx.doi.org/10.1302/2058-5241.5.190062 Text en © 2020 The author(s) https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) licence (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed.
spellingShingle Instructional Lecture: Basic Science
Gómez-Barrena, Enrique
Padilla-Eguiluz, Norma G.
Rosset, Philippe
Frontiers in non-union research
title Frontiers in non-union research
title_full Frontiers in non-union research
title_fullStr Frontiers in non-union research
title_full_unstemmed Frontiers in non-union research
title_short Frontiers in non-union research
title_sort frontiers in non-union research
topic Instructional Lecture: Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608578/
https://www.ncbi.nlm.nih.gov/pubmed/33204499
http://dx.doi.org/10.1302/2058-5241.5.190062
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