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Asymmetric dynamic coupling promotes alternative evolutionary pathways in an enzyme dimer
The importance of dynamic factors in enzyme evolution is gaining recognition. Here we study how the evolution of a new enzymatic activity exploits conformational tinkering and demonstrate that conversion of a dimeric phosphotriesterase to an arylesterase in Pseudomonas diminuta is accompanied by str...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608688/ https://www.ncbi.nlm.nih.gov/pubmed/33139795 http://dx.doi.org/10.1038/s41598-020-75772-5 |