A small UTX stabilization domain of Trr is conserved within mammalian MLL3-4/COMPASS and is sufficient to rescue loss of viability in null animals

Catalytic-inactivating mutations within the Drosophila enhancer H3K4 mono-methyltransferase Trr and its mammalian homologs, MLL3/4, cause only minor changes in gene expression compared with whole-gene deletions for these COMPASS members. To identify essential histone methyltransferase-independent fu...

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Detalles Bibliográficos
Autores principales: Rickels, Ryan, Wang, Lu, Iwanaszko, Marta, Ozark, Patrick A., Morgan, Marc A., Piunti, Andrea, Khalatyan, Natalia, Soliman, Shimaa H.A., Rendleman, Emily J., Savas, Jeffrey N., Smith, Edwin R., Shilatifard, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608747/
https://www.ncbi.nlm.nih.gov/pubmed/33033055
http://dx.doi.org/10.1101/gad.339762.120

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