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The DNA replication fork suppresses CMG unloading from chromatin before termination

When converging replication forks meet during replication termination, the CMG (Cdc45–MCM2–7–GINS) helicase is polyubiquitylated by CRL2(Lrr1) and unloaded from chromatin by the p97 ATPase. Here, we investigate the signal that triggers CMG unloading in Xenopus egg extracts using single-molecule and...

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Detalles Bibliográficos
Autores principales:	Low, Emily, Chistol, Gheorghe, Zaher, Manal S., Kochenova, Olga V., Walter, Johannes C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608748/ https://www.ncbi.nlm.nih.gov/pubmed/32943574 http://dx.doi.org/10.1101/gad.339739.120

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