Cargando…
EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism
EBF1 and PAX5 mutations are associated with the development of B progenitor acute lymphoblastic leukemia (B-ALL) in humans. To understand the molecular networks driving leukemia in the Ebf1(+/−)Pax5(+/−) (dHet) mouse model for B-ALL, we interrogated the transcriptional profiles and chromatin status...
Autores principales: | Ramamoorthy, Senthilkumar, Kometani, Kohei, Herman, Josip S., Bayer, Marc, Boller, Sören, Edwards-Hicks, Joy, Ramachandran, Haribaskar, Li, Rui, Klein-Geltink, Ramon, Pearce, Erika L., Grün, Dominic, Grosschedl, Rudolf |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608749/ https://www.ncbi.nlm.nih.gov/pubmed/33004416 http://dx.doi.org/10.1101/gad.340216.120 |
Ejemplares similares
-
Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming
por: Li, Rui, et al.
Publicado: (2018) -
Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling
por: Bayer, Marc, et al.
Publicado: (2022) -
Interaction of CCR4–NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis
por: Yang, Cheng-Yuan, et al.
Publicado: (2016) -
EBF1 is continuously required for stabilizing local chromatin accessibility in pro-B cells
por: Zolotarev, Nikolay, et al.
Publicado: (2022) -
Regulation of proliferation and survival of B-lymphocytes by Ebf1 - implications in leukaemia
por: Győry, Ildikó, et al.
Publicado: (2013)