Cargando…

Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo

Extended-release gastrointestinal (GI) luminal delivery substantially increases the ease of administration of drugs and consequently the adherence to therapeutic regimens. However, because of clearance by intrinsic GI motility, device gastroretention and extended drug release over a prolonged durati...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghosh, Arijit, Li, Ling, Xu, Liyi, Dash, Ranjeet P., Gupta, Neha, Lam, Jenny, Jin, Qianru, Akshintala, Venkata, Pahapale, Gayatri, Liu, Wangqu, Sarkar, Anjishnu, Rais, Rana, Gracias, David H., Selaru, Florin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608789/
https://www.ncbi.nlm.nih.gov/pubmed/33115736
http://dx.doi.org/10.1126/sciadv.abb4133
_version_ 1783604900430610432
author Ghosh, Arijit
Li, Ling
Xu, Liyi
Dash, Ranjeet P.
Gupta, Neha
Lam, Jenny
Jin, Qianru
Akshintala, Venkata
Pahapale, Gayatri
Liu, Wangqu
Sarkar, Anjishnu
Rais, Rana
Gracias, David H.
Selaru, Florin M.
author_facet Ghosh, Arijit
Li, Ling
Xu, Liyi
Dash, Ranjeet P.
Gupta, Neha
Lam, Jenny
Jin, Qianru
Akshintala, Venkata
Pahapale, Gayatri
Liu, Wangqu
Sarkar, Anjishnu
Rais, Rana
Gracias, David H.
Selaru, Florin M.
author_sort Ghosh, Arijit
collection PubMed
description Extended-release gastrointestinal (GI) luminal delivery substantially increases the ease of administration of drugs and consequently the adherence to therapeutic regimens. However, because of clearance by intrinsic GI motility, device gastroretention and extended drug release over a prolonged duration are very challenging. Here, we report that GI parasite–inspired active mechanochemical therapeutic grippers, or theragrippers, can reside within the GI tract of live animals for 24 hours by autonomously latching onto the mucosal tissue. We also observe a notable sixfold increase in the elimination half-life using theragripper-mediated delivery of a model analgesic ketorolac tromethamine. These results provide first-in-class evidence that shape-changing and self-latching microdevices enhance the efficacy of extended drug delivery.
format Online
Article
Text
id pubmed-7608789
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher American Association for the Advancement of Science
record_format MEDLINE/PubMed
spelling pubmed-76087892020-11-13 Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo Ghosh, Arijit Li, Ling Xu, Liyi Dash, Ranjeet P. Gupta, Neha Lam, Jenny Jin, Qianru Akshintala, Venkata Pahapale, Gayatri Liu, Wangqu Sarkar, Anjishnu Rais, Rana Gracias, David H. Selaru, Florin M. Sci Adv Research Articles Extended-release gastrointestinal (GI) luminal delivery substantially increases the ease of administration of drugs and consequently the adherence to therapeutic regimens. However, because of clearance by intrinsic GI motility, device gastroretention and extended drug release over a prolonged duration are very challenging. Here, we report that GI parasite–inspired active mechanochemical therapeutic grippers, or theragrippers, can reside within the GI tract of live animals for 24 hours by autonomously latching onto the mucosal tissue. We also observe a notable sixfold increase in the elimination half-life using theragripper-mediated delivery of a model analgesic ketorolac tromethamine. These results provide first-in-class evidence that shape-changing and self-latching microdevices enhance the efficacy of extended drug delivery. American Association for the Advancement of Science 2020-10-28 /pmc/articles/PMC7608789/ /pubmed/33115736 http://dx.doi.org/10.1126/sciadv.abb4133 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Ghosh, Arijit
Li, Ling
Xu, Liyi
Dash, Ranjeet P.
Gupta, Neha
Lam, Jenny
Jin, Qianru
Akshintala, Venkata
Pahapale, Gayatri
Liu, Wangqu
Sarkar, Anjishnu
Rais, Rana
Gracias, David H.
Selaru, Florin M.
Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo
title Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo
title_full Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo
title_fullStr Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo
title_full_unstemmed Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo
title_short Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo
title_sort gastrointestinal-resident, shape-changing microdevices extend drug release in vivo
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608789/
https://www.ncbi.nlm.nih.gov/pubmed/33115736
http://dx.doi.org/10.1126/sciadv.abb4133
work_keys_str_mv AT ghosharijit gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo
AT liling gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo
AT xuliyi gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo
AT dashranjeetp gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo
AT guptaneha gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo
AT lamjenny gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo
AT jinqianru gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo
AT akshintalavenkata gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo
AT pahapalegayatri gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo
AT liuwangqu gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo
AT sarkaranjishnu gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo
AT raisrana gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo
AT graciasdavidh gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo
AT selaruflorinm gastrointestinalresidentshapechangingmicrodevicesextenddrugreleaseinvivo