Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts

Aberrant number and/or dysfunction of CD4(+)Foxp3(+) Regulatory T cells (T(regs)) are associated with the pathogenesis of rheumatoid arthritis (RA). A previous study has demonstrated that thymus-derived, natural T(regs) (nT(regs)) prefer to accumulate in inflamed joints and transdifferentiate to T(H...

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Detalles Bibliográficos
Autores principales: Yang, Sujuan, Zhang, Ximei, Chen, Jingrong, Dang, Junlong, Liang, Rongzhen, Zeng, Donglan, Zhang, Huan, Xue, Youqiu, Liu, Yan, Wu, Wenbin, Zhao, Jun, Wang, Julie, Pan, Yunfeng, Xu, Hanshi, Sun, Bing, Huang, Feng, Lu, Yan, Hsueh, Willa, Olsen, Nancy, Zheng, Song Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608803/
https://www.ncbi.nlm.nih.gov/pubmed/33115734
http://dx.doi.org/10.1126/sciadv.abb0606

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