VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcription

VGLL4 has been identified as a YAP inhibitor. However, the exact function of VGLL4 in bone development and bone homeostasis remains unclear. In this study, we demonstrated that VGLL4 breaks TEADs-mediated transcriptional inhibition of RUNX2 to promote osteoblast differentiation and bone development....

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Detalles Bibliográficos
Autores principales: Suo, Jinlong, Feng, Xue, Li, Jiayi, Wang, Jinghui, Wang, Zuoyun, Zhang, Lei, Zou, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608831/
https://www.ncbi.nlm.nih.gov/pubmed/33097532
http://dx.doi.org/10.1126/sciadv.aba4147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608831/
https://www.ncbi.nlm.nih.gov/pubmed/33097532
http://dx.doi.org/10.1126/sciadv.aba4147

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