RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis

Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal translocation, EWSR1-FLI1 being the most common, that causes genome reprogramming through remodeling of enhancers. Here, we describe an unexpected function of RING1B, which is highly...

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Detalles Bibliográficos
Autores principales: Sánchez-Molina, Sara, Figuerola-Bou, Elisabet, Blanco, Enrique, Sánchez-Jiménez, María, Táboas, Pablo, Gómez, Soledad, Ballaré, Cecilia, García-Domínguez, Daniel J., Prada, Estela, Hontecillas-Prieto, Lourdes, M. Carcaboso, Ángel, Tirado, Óscar M., Hernández-Muñoz, Inmaculada, de Álava, Enrique, Lavarino, Cinzia, Di Croce, Luciano, Mora, Jaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608835/
https://www.ncbi.nlm.nih.gov/pubmed/33097530
http://dx.doi.org/10.1126/sciadv.aba3058

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