Cargando…

LocusFocus: Web-based colocalization for the annotation and functional follow-up of GWAS

Genome-wide association studies (GWAS) have primarily identified trait-associated loci in the non-coding genome. Colocalization analyses of SNP associations from GWAS with expression quantitative trait loci (eQTL) evidence enable the generation of hypotheses about responsible mechanism, genes and ti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Panjwani, Naim, Wang, Fan, Mastromatteo, Scott, Bao, Allen, Wang, Cheng, He, Gengming, Gong, Jiafen, Rommens, Johanna M., Sun, Lei, Strug, Lisa J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608978/ https://www.ncbi.nlm.nih.gov/pubmed/33090994 http://dx.doi.org/10.1371/journal.pcbi.1008336

Ejemplares similares

A flexible summary statistics-based colocalization method with application to the mucin cystic fibrosis lung disease modifier locus
por: Wang, Fan, et al.
Publicado: (2022)

ColocQuiaL: a QTL-GWAS colocalization pipeline
por: Chen, Brian Y, et al.
Publicado: (2022)

ezQTL: A Web Platform for Interactive Visualization and Colocalization of QTLs and GWAS Loci
por: Zhang, Tongwu, et al.
Publicado: (2022)

A Joint Location-Scale Test Improves Power to Detect Associated SNPs, Gene Sets, and Pathways
por: Soave, David, et al.
Publicado: (2015)

Genetic association and transcriptome integration identify contributing genes and tissues at cystic fibrosis modifier loci
por: Gong, Jiafen, et al.
Publicado: (2019)

Improving imputation in disease-relevant regions: lessons from cystic fibrosis
por: Panjwani, Naim, et al.
Publicado: (2018)

LocusTrack: Integrated visualization of GWAS results and genomic annotation
por: Cuellar-Partida, Gabriel, et al.
Publicado: (2015)

VikNGS: a C++ variant integration kit for next generation sequencing association analysis
por: Baskurt, Zeynep, et al.
Publicado: (2020)

Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx
por: Gay, Nicole R., et al.
Publicado: (2020)

Cystic fibrosis gene modifier SLC26A9 modulates airway response to CFTR-directed therapeutics
por: Strug, Lisa J., et al.
Publicado: (2016)

Coloc-stats: a unified web interface to perform colocalization analysis of genomic features
por: Simovski, Boris, et al.
Publicado: (2018)

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
por: Franceschini, Nora, et al.
Publicado: (2018)

ColoWeb: a resource for analysis of colocalization of genomic features
por: Kim, RyangGuk, et al.
Publicado: (2015)

Qtlizer: comprehensive QTL annotation of GWAS results
por: Munz, Matthias, et al.
Publicado: (2020)

Identification and Functional Annotation of Genes Related to Horses’ Performance: From GWAS to Post-GWAS
por: Littiere, Thayssa O., et al.
Publicado: (2020)

Kerfuffle: a web tool for multi-species gene colocalization analysis
por: Aboukhalil, Robert, et al.
Publicado: (2013)

eQTpLot: a user-friendly R package for the visualization of colocalization between eQTL and GWAS signals
por: Drivas, Theodore G., et al.
Publicado: (2021)

Genetic evidence supports the development of SLC26A9 targeting therapies for the treatment of lung disease
por: Gong, Jiafen, et al.
Publicado: (2022)

Using Gene Expression to Annotate Cardiovascular GWAS Loci
por: Heinig, Matthias
Publicado: (2018)

Evidence for a Causal Relationship Between Early Exocrine Pancreatic Disease and Cystic Fibrosis–Related Diabetes: A Mendelian Randomization Study
por: Soave, David, et al.
Publicado: (2014)

Colocalization of blood cell traits GWAS associations and variation in PU.1 genomic occupancy prioritizes causal noncoding regulatory variants
por: Jeong, Raehoon, et al.
Publicado: (2023)

Blood cell traits’ GWAS loci colocalization with variation in PU.1 genomic occupancy prioritizes causal noncoding regulatory variants
por: Jeong, Raehoon, et al.
Publicado: (2023)

Identification of southern corn rust resistance QTNs in Chinese summer maize germplasm via multi-locus GWAS and post-GWAS analysis
por: Shu, Guoping, et al.
Publicado: (2023)

Identifying multiple causative genes at a single GWAS locus
por: Flister, Michael J., et al.
Publicado: (2013)

Gene mapping and functional annotation of GWAS of oral ulcers using FUMA software
por: Jin, Xiaoye, et al.
Publicado: (2020)

WHIDE—a web tool for visual data mining colocation patterns in multivariate bioimages
por: Kölling, Jan, et al.
Publicado: (2012)

The Application of Multi-Locus GWAS for the Detection of Salt-Tolerance Loci in Rice
por: Cui, Yanru, et al.
Publicado: (2018)

EzColocalization: An ImageJ plugin for visualizing and measuring colocalization in cells and organisms
por: Stauffer, Weston, et al.
Publicado: (2018)

Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations
por: Al-Barghouthi, Basel Maher, et al.
Publicado: (2022)

Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS
por: Wang, Yunpeng, et al.
Publicado: (2016)

Predicting gene ontology annotations of orphan GWAS genes using protein-protein interactions
por: Kuppuswamy, Usha, et al.
Publicado: (2014)

Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci
por: Trynka, Gosia, et al.
Publicado: (2015)

Identification of a novel uterine leiomyoma GWAS locus in a Japanese population
por: Sakai, Kensuke, et al.
Publicado: (2020)

GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus
por: Sleiman, Patrick, et al.
Publicado: (2013)

epiCOLOC: Integrating Large-Scale and Context-Dependent Epigenomics Features for Comprehensive Colocalization Analysis
por: Zhou, Yao, et al.
Publicado: (2020)

GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation
por: Chung, Dongjun, et al.
Publicado: (2014)

Colocalization of corneal resistance factor GWAS loci with GTEx e/sQTLs highlights plausible candidate causal genes for keratoconus postnatal corneal stroma weakening
por: Jiang, Xinyi, et al.
Publicado: (2023)

TR Locus Annotation and Characteristics of Rhinolophus ferrumequinum
por: Zhou, Hao, et al.
Publicado: (2021)

GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology
por: Bovijn, Jonas, et al.
Publicado: (2019)

A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus
por: Mobuchon, Lenha, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ufnb7dkh5cnqhi4oik9dih3pbt