Allosteric inhibition of LRRK2, where are we now

Parkinson's disease (PD) is the second most common neurodegenerative disease. In recent years, it has been shown that leucine-rich repeat kinase 2 (LRRK2) has a crucial function in both familial and sporadic forms of PD. LRRK2 pathogenic mutations are thought to result in an increase in LRRK2 k...

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Detalles Bibliográficos
Autores principales: Soliman, Ahmed, Cankara, Fatma Nihan, Kortholt, Arjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609032/
https://www.ncbi.nlm.nih.gov/pubmed/33079169
http://dx.doi.org/10.1042/BST20200424

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