Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations

LRRK2 is a kinase expressed in striatal spiny projection neurons (SPNs), cells which lose dopaminergic input in Parkinson’s disease (PD). R1441C and G2019S are the most common pathogenic mutations of LRRK2. How these mutations alter the structure and function of individual synapses on direct and ind...

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Detalles Bibliográficos
Autores principales: Chen, Chuyu, Soto, Giulia, Dumrongprechachan, Vasin, Bannon, Nicholas, Kang, Shuo, Kozorovitskiy, Yevgenia, Parisiadou, Loukia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609054/
https://www.ncbi.nlm.nih.gov/pubmed/33006315
http://dx.doi.org/10.7554/eLife.58997

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