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Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial Infection

Mycobacterium tuberculosis (Mtb) is an etiologic pathogen of human tuberculosis (TB), a serious infectious disease with high morbidity and mortality. In addition, the threat of drug resistance in anti-TB therapy is of global concern. Despite this, it remains urgent to research for understanding the...

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Autores principales: Kim, Jin Kyung, Silwal, Prashanta, Jo, Eun-Kyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609165/
https://www.ncbi.nlm.nih.gov/pubmed/33163245
http://dx.doi.org/10.4110/in.2020.20.e37
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author Kim, Jin Kyung
Silwal, Prashanta
Jo, Eun-Kyeong
author_facet Kim, Jin Kyung
Silwal, Prashanta
Jo, Eun-Kyeong
author_sort Kim, Jin Kyung
collection PubMed
description Mycobacterium tuberculosis (Mtb) is an etiologic pathogen of human tuberculosis (TB), a serious infectious disease with high morbidity and mortality. In addition, the threat of drug resistance in anti-TB therapy is of global concern. Despite this, it remains urgent to research for understanding the molecular nature of dynamic interactions between host and pathogens during TB infection. While Mtb evasion from phagolysosomal acidification is a well-known virulence mechanism, the molecular events to promote intracellular parasitism remains elusive. To combat intracellular Mtb infection, several defensive processes, including autophagy and apoptosis, are activated. In addition, Mtb-ingested phagocytes trigger inflammation, and undergo necrotic cell death, potentially harmful responses in case of uncontrolled pathological condition. In this review, we focus on Mtb evasion from phagosomal acidification, and Mtb interaction with host autophagy, apoptosis, and necrosis. Elucidation of the molecular dialogue will shed light on Mtb pathogenesis, host defense, and development of new paradigms of therapeutics.
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spelling pubmed-76091652020-11-06 Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial Infection Kim, Jin Kyung Silwal, Prashanta Jo, Eun-Kyeong Immune Netw Review Article Mycobacterium tuberculosis (Mtb) is an etiologic pathogen of human tuberculosis (TB), a serious infectious disease with high morbidity and mortality. In addition, the threat of drug resistance in anti-TB therapy is of global concern. Despite this, it remains urgent to research for understanding the molecular nature of dynamic interactions between host and pathogens during TB infection. While Mtb evasion from phagolysosomal acidification is a well-known virulence mechanism, the molecular events to promote intracellular parasitism remains elusive. To combat intracellular Mtb infection, several defensive processes, including autophagy and apoptosis, are activated. In addition, Mtb-ingested phagocytes trigger inflammation, and undergo necrotic cell death, potentially harmful responses in case of uncontrolled pathological condition. In this review, we focus on Mtb evasion from phagosomal acidification, and Mtb interaction with host autophagy, apoptosis, and necrosis. Elucidation of the molecular dialogue will shed light on Mtb pathogenesis, host defense, and development of new paradigms of therapeutics. The Korean Association of Immunologists 2020-10-23 /pmc/articles/PMC7609165/ /pubmed/33163245 http://dx.doi.org/10.4110/in.2020.20.e37 Text en Copyright © 2020. The Korean Association of Immunologists https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Jin Kyung
Silwal, Prashanta
Jo, Eun-Kyeong
Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial Infection
title Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial Infection
title_full Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial Infection
title_fullStr Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial Infection
title_full_unstemmed Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial Infection
title_short Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial Infection
title_sort host-pathogen dialogues in autophagy, apoptosis, and necrosis during mycobacterial infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609165/
https://www.ncbi.nlm.nih.gov/pubmed/33163245
http://dx.doi.org/10.4110/in.2020.20.e37
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