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Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer
Emerging evidence supports that oral microbiota are associated with health and diseases of the esophagus. How oral microbiota change in Chinese patients with esophageal cancer (EC) is unknown, neither is their biomarker role. For an objective to understand alterations of oral microbiota in Chinese E...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609410/ https://www.ncbi.nlm.nih.gov/pubmed/33194789 http://dx.doi.org/10.3389/fcimb.2020.541144 |
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author | Zhao, Qiaofei Yang, Tian Yan, Yifan Zhang, Yu Li, Zhibin Wang, Youchun Yang, Jing Xia, Yanli Xiao, Hongli Han, Hongfeng Zhang, Chunfen Xue, Weihong Zhao, Hongyi Chen, Hongwei Wang, Baoyong |
author_facet | Zhao, Qiaofei Yang, Tian Yan, Yifan Zhang, Yu Li, Zhibin Wang, Youchun Yang, Jing Xia, Yanli Xiao, Hongli Han, Hongfeng Zhang, Chunfen Xue, Weihong Zhao, Hongyi Chen, Hongwei Wang, Baoyong |
author_sort | Zhao, Qiaofei |
collection | PubMed |
description | Emerging evidence supports that oral microbiota are associated with health and diseases of the esophagus. How oral microbiota change in Chinese patients with esophageal cancer (EC) is unknown, neither is their biomarker role. For an objective to understand alterations of oral microbiota in Chinese EC patients, we conducted a case-control study including saliva samples from 39 EC patients and 51 healthy volunteers. 16S rDNA genes of V3-V4 variable regions were sequenced to identify taxon. Relationship between oral flora and disease was analyzed according to alpha diversity and beta diversity. Resultantly, the Shannon index (p = 0.2) and the Simpson diversity index (p = 0.071) were not significant between the two groups. Yet we still found several species different in abundance between the two groups. For the EC group, the most significantly increased taxa were Firmicutes, Negativicutes, Selenomonadales, Prevotellaceae, Prevotella, and Veillonellaceae, while the most significantly decreased taxa were Proteobacteria, Betaproteobacteria, Neisseriales, Neisseriaceae, and Neisseria. In conclusion, there are significant alterations in abundance of some oral microbiomes between the EC patients and the healthy controls in the studied Chinese participants, which may be meaningful for predicting the development of EC, and the potential roles of these species in EC development deserve further studies. |
format | Online Article Text |
id | pubmed-7609410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76094102020-11-13 Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer Zhao, Qiaofei Yang, Tian Yan, Yifan Zhang, Yu Li, Zhibin Wang, Youchun Yang, Jing Xia, Yanli Xiao, Hongli Han, Hongfeng Zhang, Chunfen Xue, Weihong Zhao, Hongyi Chen, Hongwei Wang, Baoyong Front Cell Infect Microbiol Cellular and Infection Microbiology Emerging evidence supports that oral microbiota are associated with health and diseases of the esophagus. How oral microbiota change in Chinese patients with esophageal cancer (EC) is unknown, neither is their biomarker role. For an objective to understand alterations of oral microbiota in Chinese EC patients, we conducted a case-control study including saliva samples from 39 EC patients and 51 healthy volunteers. 16S rDNA genes of V3-V4 variable regions were sequenced to identify taxon. Relationship between oral flora and disease was analyzed according to alpha diversity and beta diversity. Resultantly, the Shannon index (p = 0.2) and the Simpson diversity index (p = 0.071) were not significant between the two groups. Yet we still found several species different in abundance between the two groups. For the EC group, the most significantly increased taxa were Firmicutes, Negativicutes, Selenomonadales, Prevotellaceae, Prevotella, and Veillonellaceae, while the most significantly decreased taxa were Proteobacteria, Betaproteobacteria, Neisseriales, Neisseriaceae, and Neisseria. In conclusion, there are significant alterations in abundance of some oral microbiomes between the EC patients and the healthy controls in the studied Chinese participants, which may be meaningful for predicting the development of EC, and the potential roles of these species in EC development deserve further studies. Frontiers Media S.A. 2020-10-21 /pmc/articles/PMC7609410/ /pubmed/33194789 http://dx.doi.org/10.3389/fcimb.2020.541144 Text en Copyright © 2020 Zhao, Yang, Yan, Zhang, Li, Wang, Yang, Xia, Xiao, Han, Zhang, Xue, Zhao, Chen and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Zhao, Qiaofei Yang, Tian Yan, Yifan Zhang, Yu Li, Zhibin Wang, Youchun Yang, Jing Xia, Yanli Xiao, Hongli Han, Hongfeng Zhang, Chunfen Xue, Weihong Zhao, Hongyi Chen, Hongwei Wang, Baoyong Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer |
title | Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer |
title_full | Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer |
title_fullStr | Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer |
title_full_unstemmed | Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer |
title_short | Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer |
title_sort | alterations of oral microbiota in chinese patients with esophageal cancer |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609410/ https://www.ncbi.nlm.nih.gov/pubmed/33194789 http://dx.doi.org/10.3389/fcimb.2020.541144 |
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