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Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer

Emerging evidence supports that oral microbiota are associated with health and diseases of the esophagus. How oral microbiota change in Chinese patients with esophageal cancer (EC) is unknown, neither is their biomarker role. For an objective to understand alterations of oral microbiota in Chinese E...

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Autores principales: Zhao, Qiaofei, Yang, Tian, Yan, Yifan, Zhang, Yu, Li, Zhibin, Wang, Youchun, Yang, Jing, Xia, Yanli, Xiao, Hongli, Han, Hongfeng, Zhang, Chunfen, Xue, Weihong, Zhao, Hongyi, Chen, Hongwei, Wang, Baoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609410/
https://www.ncbi.nlm.nih.gov/pubmed/33194789
http://dx.doi.org/10.3389/fcimb.2020.541144
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author Zhao, Qiaofei
Yang, Tian
Yan, Yifan
Zhang, Yu
Li, Zhibin
Wang, Youchun
Yang, Jing
Xia, Yanli
Xiao, Hongli
Han, Hongfeng
Zhang, Chunfen
Xue, Weihong
Zhao, Hongyi
Chen, Hongwei
Wang, Baoyong
author_facet Zhao, Qiaofei
Yang, Tian
Yan, Yifan
Zhang, Yu
Li, Zhibin
Wang, Youchun
Yang, Jing
Xia, Yanli
Xiao, Hongli
Han, Hongfeng
Zhang, Chunfen
Xue, Weihong
Zhao, Hongyi
Chen, Hongwei
Wang, Baoyong
author_sort Zhao, Qiaofei
collection PubMed
description Emerging evidence supports that oral microbiota are associated with health and diseases of the esophagus. How oral microbiota change in Chinese patients with esophageal cancer (EC) is unknown, neither is their biomarker role. For an objective to understand alterations of oral microbiota in Chinese EC patients, we conducted a case-control study including saliva samples from 39 EC patients and 51 healthy volunteers. 16S rDNA genes of V3-V4 variable regions were sequenced to identify taxon. Relationship between oral flora and disease was analyzed according to alpha diversity and beta diversity. Resultantly, the Shannon index (p = 0.2) and the Simpson diversity index (p = 0.071) were not significant between the two groups. Yet we still found several species different in abundance between the two groups. For the EC group, the most significantly increased taxa were Firmicutes, Negativicutes, Selenomonadales, Prevotellaceae, Prevotella, and Veillonellaceae, while the most significantly decreased taxa were Proteobacteria, Betaproteobacteria, Neisseriales, Neisseriaceae, and Neisseria. In conclusion, there are significant alterations in abundance of some oral microbiomes between the EC patients and the healthy controls in the studied Chinese participants, which may be meaningful for predicting the development of EC, and the potential roles of these species in EC development deserve further studies.
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spelling pubmed-76094102020-11-13 Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer Zhao, Qiaofei Yang, Tian Yan, Yifan Zhang, Yu Li, Zhibin Wang, Youchun Yang, Jing Xia, Yanli Xiao, Hongli Han, Hongfeng Zhang, Chunfen Xue, Weihong Zhao, Hongyi Chen, Hongwei Wang, Baoyong Front Cell Infect Microbiol Cellular and Infection Microbiology Emerging evidence supports that oral microbiota are associated with health and diseases of the esophagus. How oral microbiota change in Chinese patients with esophageal cancer (EC) is unknown, neither is their biomarker role. For an objective to understand alterations of oral microbiota in Chinese EC patients, we conducted a case-control study including saliva samples from 39 EC patients and 51 healthy volunteers. 16S rDNA genes of V3-V4 variable regions were sequenced to identify taxon. Relationship between oral flora and disease was analyzed according to alpha diversity and beta diversity. Resultantly, the Shannon index (p = 0.2) and the Simpson diversity index (p = 0.071) were not significant between the two groups. Yet we still found several species different in abundance between the two groups. For the EC group, the most significantly increased taxa were Firmicutes, Negativicutes, Selenomonadales, Prevotellaceae, Prevotella, and Veillonellaceae, while the most significantly decreased taxa were Proteobacteria, Betaproteobacteria, Neisseriales, Neisseriaceae, and Neisseria. In conclusion, there are significant alterations in abundance of some oral microbiomes between the EC patients and the healthy controls in the studied Chinese participants, which may be meaningful for predicting the development of EC, and the potential roles of these species in EC development deserve further studies. Frontiers Media S.A. 2020-10-21 /pmc/articles/PMC7609410/ /pubmed/33194789 http://dx.doi.org/10.3389/fcimb.2020.541144 Text en Copyright © 2020 Zhao, Yang, Yan, Zhang, Li, Wang, Yang, Xia, Xiao, Han, Zhang, Xue, Zhao, Chen and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Zhao, Qiaofei
Yang, Tian
Yan, Yifan
Zhang, Yu
Li, Zhibin
Wang, Youchun
Yang, Jing
Xia, Yanli
Xiao, Hongli
Han, Hongfeng
Zhang, Chunfen
Xue, Weihong
Zhao, Hongyi
Chen, Hongwei
Wang, Baoyong
Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer
title Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer
title_full Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer
title_fullStr Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer
title_full_unstemmed Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer
title_short Alterations of Oral Microbiota in Chinese Patients With Esophageal Cancer
title_sort alterations of oral microbiota in chinese patients with esophageal cancer
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609410/
https://www.ncbi.nlm.nih.gov/pubmed/33194789
http://dx.doi.org/10.3389/fcimb.2020.541144
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