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Zebrafish as a model to study autophagy and its role in skeletal development and disease

In the last twenty years, research using zebrafish as a model organism has increased immensely. With the many advantages that zebrafish offer such as high fecundity, optical transparency, ex vivo development, and genetic tractability, they are well suited to studying developmental processes and the...

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Autores principales: Moss, Joanna J., Hammond, Chrissy L., Lane, Jon D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609422/
https://www.ncbi.nlm.nih.gov/pubmed/32915267
http://dx.doi.org/10.1007/s00418-020-01917-2
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author Moss, Joanna J.
Hammond, Chrissy L.
Lane, Jon D.
author_facet Moss, Joanna J.
Hammond, Chrissy L.
Lane, Jon D.
author_sort Moss, Joanna J.
collection PubMed
description In the last twenty years, research using zebrafish as a model organism has increased immensely. With the many advantages that zebrafish offer such as high fecundity, optical transparency, ex vivo development, and genetic tractability, they are well suited to studying developmental processes and the effect of genetic mutations. More recently, zebrafish models have been used to study autophagy. This important protein degradation pathway is needed for cell and tissue homeostasis in a variety of contexts. Correspondingly, its dysregulation has been implicated in multiple diseases including skeletal disorders. In this review, we explore how zebrafish are being used to study autophagy in the context of skeletal development and disease, and the ways these areas are intersecting to help identify potential therapeutic targets for skeletal disorders.
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spelling pubmed-76094222020-11-10 Zebrafish as a model to study autophagy and its role in skeletal development and disease Moss, Joanna J. Hammond, Chrissy L. Lane, Jon D. Histochem Cell Biol Review In the last twenty years, research using zebrafish as a model organism has increased immensely. With the many advantages that zebrafish offer such as high fecundity, optical transparency, ex vivo development, and genetic tractability, they are well suited to studying developmental processes and the effect of genetic mutations. More recently, zebrafish models have been used to study autophagy. This important protein degradation pathway is needed for cell and tissue homeostasis in a variety of contexts. Correspondingly, its dysregulation has been implicated in multiple diseases including skeletal disorders. In this review, we explore how zebrafish are being used to study autophagy in the context of skeletal development and disease, and the ways these areas are intersecting to help identify potential therapeutic targets for skeletal disorders. Springer Berlin Heidelberg 2020-09-11 2020 /pmc/articles/PMC7609422/ /pubmed/32915267 http://dx.doi.org/10.1007/s00418-020-01917-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Moss, Joanna J.
Hammond, Chrissy L.
Lane, Jon D.
Zebrafish as a model to study autophagy and its role in skeletal development and disease
title Zebrafish as a model to study autophagy and its role in skeletal development and disease
title_full Zebrafish as a model to study autophagy and its role in skeletal development and disease
title_fullStr Zebrafish as a model to study autophagy and its role in skeletal development and disease
title_full_unstemmed Zebrafish as a model to study autophagy and its role in skeletal development and disease
title_short Zebrafish as a model to study autophagy and its role in skeletal development and disease
title_sort zebrafish as a model to study autophagy and its role in skeletal development and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609422/
https://www.ncbi.nlm.nih.gov/pubmed/32915267
http://dx.doi.org/10.1007/s00418-020-01917-2
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