Cargando…

Identification of Theaflavin-3,3’-Digallate as a Novel Zika Virus Protease Inhibitor

Mounting evidence indicates that Zika virus (ZIKV) is closely related to neurological disorders such as microcephaly and Guillain-Barré syndrome. There are currently no effective vaccines and FDA-approved inhibitors against ZIKV infection. The flaviviral heterodimeric serine protease NS2B-NS3 plays...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cui, Xiangling, Zhou, Rui, Huang, Chenchao, Zhang, Rongyu, Wang, Jing, Zhang, Yongxin, Ding, Jiwei, Li, Xiaoyu, Zhou, Jinming, Cen, Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609463/ https://www.ncbi.nlm.nih.gov/pubmed/33192499 http://dx.doi.org/10.3389/fphar.2020.514313

Ejemplares similares

Antibacterial and Sporicidal Activity Evaluation of Theaflavin-3,3′-digallate
por: Yussof, Ayuni, et al.
Publicado: (2022)

Theaflavin-3,3′-Digallate Promotes the Formation of Osteoblasts Under Inflammatory Environment and Increases the Bone Mass of Ovariectomized Mice
por: Ge, Gaoran, et al.
Publicado: (2021)

Inhibition of α-hemolysin activity of Staphylococcus aureus by theaflavin 3,3’-digallate
por: Goc, Anna, et al.
Publicado: (2023)

Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3′-digallate (TF3)
por: Chen, Chia-Nan, et al.
Publicado: (2005)

Theaflavin-3,3′-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways
por: Teng, Yun, et al.
Publicado: (2022)

Theaflavin-3,3′-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells
por: Wu, Yichen, et al.
Publicado: (2022)

Microbial Metabolism of Theaflavin-3,3′-digallate and Its Gut Microbiota Composition Modulatory Effects
por: Liu, Zhibin, et al.
Publicado: (2020)

Theaflavin-3, 3′-Digallate Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Ovariectomy-Induced Bone Loss in Mice
por: Ai, Zexin, et al.
Publicado: (2020)

Theaflavin-3,3’-Digallate Ameliorates Collagen-Induced Arthritis Through Regulation of Autophagy and Macrophage Polarization
por: Zhang, Lei, et al.
Publicado: (2023)

Improving Theaflavin-3,3′-digallate Production Efficiency Optimization by Transition State Conformation of Polyphenol Oxidase
por: Huang, Ying, et al.
Publicado: (2023)

Effect of theaflavin-3,3′-digallate on leptin-deficient induced nonalcoholic fatty liver disease might be related to lipid metabolism regulated by the Fads1/PPARδ/Fabp4 axis and gut microbiota
por: Zhou, Cheng, et al.
Publicado: (2022)

Theaflavin-3,3'-digallate attenuates cigarette smoke extract-induced pulmonary emphysema in mice by suppressing necroptosis
por: Luan, Guangxin, et al.
Publicado: (2022)

Theaflavin‐3,3´‐digallate increases the antibacterial activity of β‐lactam antibiotics by inhibiting metallo‐β‐lactamase activity
por: Teng, Zihao, et al.
Publicado: (2019)

Pre-treated theaflavin-3,3′-digallate has a higher inhibitory effect on the HCT116 cell line
por: Ding, Yangping, et al.
Publicado: (2017)

Simultaneous Tests of Theaflavin-3,3′-digallate as an Anti-Diabetic Drug in Human Hepatoma G2 Cells and Zebrafish (Danio rerio)
por: Zhou, Hui, et al.
Publicado: (2021)

Theaflavin-3,3′-Digallate Inhibits Erastin-Induced Chondrocytes Ferroptosis via the Nrf2/GPX4 Signaling Pathway in Osteoarthritis
por: Xu, Chao, et al.
Publicado: (2022)

Theaflavin-3,3′-Digallate Suppresses Biofilm Formation, Acid Production, and Acid Tolerance in Streptococcus mutans by Targeting Virulence Factors
por: Wang, Sa, et al.
Publicado: (2019)

Inhibitory effect of theaflavin-3,3′-digallate can involve its binding to the “stem” domain of α-hemolysin of Staphylococcus aureus
por: Goc, Anna, et al.
Publicado: (2023)

Potential quorum-sensing inhibitor of Hafnia alvei H4—theaflavin-3,3´-digallate analyzed by virtual screening and molecular simulation
por: Li, Xue, et al.
Publicado: (2023)

Effects of Methylmercury and Theaflavin Digallate on Adipokines in Mature 3T3-L1 Adipocytes
por: Chauhan, Shubhangi, et al.
Publicado: (2019)

The Prevention Role of Theaflavin-3,3′-digallate in Angiotensin II Induced Pathological Cardiac Hypertrophy via CaN-NFAT Signal Pathway
por: Zhou, Hui, et al.
Publicado: (2022)

Theaflavin-3,3′-Digallate Enhances the Inhibitory Effect of Cisplatin by Regulating the Copper Transporter 1 and Glutathione in Human Ovarian Cancer Cells
por: Pan, Haibo, et al.
Publicado: (2018)

Exploring the Potential Role of Theaflavin-3,3′-Digallate in Inhibiting Various Stages of SARS-CoV-2 Life Cycle: An In-Silico Approach
por: Jain, Manav, et al.
Publicado: (2022)

Theaflavin 3, 3′-Digallate Delays Ovarian Aging by Improving Oocyte Quality and Regulating Granulosa Cell Function
por: He, Jiahuan, et al.
Publicado: (2021)

Theaflavin-3,3′-Digallate Suppresses Human Ovarian Carcinoma OVCAR-3 Cells by Regulating the Checkpoint Kinase 2 and p27 kip1 Pathways
por: Gao, Ying, et al.
Publicado: (2019)

Antiviral activity of theaflavin digallate against herpes simplex virus type 1
por: de Oliveira, Aline, et al.
Publicado: (2015)

Theaflavin-3,3′-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts
por: He, Tao, et al.
Publicado: (2022)

Computational molecular interaction between SARS-CoV-2 main protease and theaflavin digallate using free energy perturbation and molecular dynamics
por: Manish, Manish, et al.
Publicado: (2022)

A molecular docking study of EGCG and theaflavin digallate with the druggable targets of SARS-CoV-2
por: Mhatre, Susmit, et al.
Publicado: (2021)

STING modulators: Predictive significance in drug discovery
por: Cui, Xiangling, et al.
Publicado: (2019)

Theaflavin-3, 3′-digallate decreases human ovarian carcinoma OVCAR-3 cell-induced angiogenesis via Akt and Notch-1 pathways, not via MAPK pathways
por: GAO, YING, et al.
Publicado: (2015)

Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site
por: Liu, Yangguang, et al.
Publicado: (2018)

Theaflavin Induces Apoptosis of A375 Human Melanoma Cells and Inhibits Tumor Growth in Xenograft Zebrafishes Through P53- and JNK-Related Mechanism
por: Zhang, Lei, et al.
Publicado: (2020)

Theaflavin-3, 3′-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells
por: TU, YOUYING, et al.
Publicado: (2016)

Identification and characterization of loop7 motif and its role in regulating biological function of human APOBEC3G through molecular modeling and biological assay
por: Zhai, Congjie, et al.
Publicado: (2017)

A High Throughput Cell-Based Screen Assay for LINE-1 ORF1p Expression Inhibitors Using the In-Cell Western Technique
por: Kou, Yanni, et al.
Publicado: (2022)

Theaflavin Chemistry and Its Health Benefits
por: Shan, Zhiguo, et al.
Publicado: (2021)

Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In Vitro
por: Jang, Minsu, et al.
Publicado: (2020)

Investigation of the Azorean Camellia sinensis Processing Conditions to Maximize the Theaflavin 3,3′-di-O-Gallate Content as a Potential Antiviral Compound
por: Paiva, Lisete, et al.
Publicado: (2022)

Synthesis of Theaflavins and Their Functions
por: Takemoto, Masumi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_qnr3kkmidcoteirugu897a2l8p