Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients

Genomic studies performed in cancer patients and tumor-derived cell lines have identified a high frequency of alterations in components of the mammalian switch/sucrose non-fermentable (mSWI/SNF or BAF) chromatin remodeling complex, including its core catalytic subunit, SMARCA4. Cells exhibiting loss...

Descripción completa

Detalles Bibliográficos
Autores principales: Fernando, Tharu M., Piskol, Robert, Bainer, Russell, Sokol, Ethan S., Trabucco, Sally E., Zhang, Qing, Trinh, Huong, Maund, Sophia, Kschonsak, Marc, Chaudhuri, Subhra, Modrusan, Zora, Januario, Thomas, Yauch, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609548/
https://www.ncbi.nlm.nih.gov/pubmed/33144586
http://dx.doi.org/10.1038/s41467-020-19402-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609548/
https://www.ncbi.nlm.nih.gov/pubmed/33144586
http://dx.doi.org/10.1038/s41467-020-19402-8

Ejemplares similares