Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice

Progranulin is a secreted neurotrophin that assists in the autophagolysosomal pathways that contribute to MHC-mediated antigen processing, pathogen removal, and autoimmunity. We showed that patients with multiple sclerosis (MS) have high levels of circulating progranulin and that its depletion in a...

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Detalles Bibliográficos
Autores principales: Schmitz, Katja, Wilken-Schmitz, Annett, Vasic, Verica, Brunkhorst, Robert, Schmidt, Mirko, Tegeder, Irmgard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609649/
https://www.ncbi.nlm.nih.gov/pubmed/31467413
http://dx.doi.org/10.1038/s41423-019-0274-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609649/
https://www.ncbi.nlm.nih.gov/pubmed/31467413
http://dx.doi.org/10.1038/s41423-019-0274-5

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