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Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis

Canine babesiosis may cause several hematological and biochemical changes, but only limited studies are available regarding the possible differences of changes in animals infected by different Babesia parasites. The study focused on the evaluation of the differences in serum protein electrophoretic...

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Autores principales: Tóthová, Csilla, Karasová, Martina, Blaňarová, Lucia, Fialkovičová, Mária, Nagy, Oskar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609656/
https://www.ncbi.nlm.nih.gov/pubmed/33144631
http://dx.doi.org/10.1038/s41598-020-75908-7
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author Tóthová, Csilla
Karasová, Martina
Blaňarová, Lucia
Fialkovičová, Mária
Nagy, Oskar
author_facet Tóthová, Csilla
Karasová, Martina
Blaňarová, Lucia
Fialkovičová, Mária
Nagy, Oskar
author_sort Tóthová, Csilla
collection PubMed
description Canine babesiosis may cause several hematological and biochemical changes, but only limited studies are available regarding the possible differences of changes in animals infected by different Babesia parasites. The study focused on the evaluation of the differences in serum protein electrophoretic pattern between dogs naturally infected with B. gibsoni (17 dogs) and B. canis (40 dogs). The mean values of total proteins, β(1)-, β(2)- and γ-globulins were in dogs infected with B. gibsoni significantly higher (P < 0.05 and P < 0.001) than in dogs infected with B. canis. The relative concentrations of albumin, α(1)-, α(2)-globulins and the A/G ratios were in the B. gibsoni infected dogs significantly lower (P < 0.001), no significant differences were found in the relative concentrations of β(1)- and β(2)-globulins. Significant differences were found in most of the evaluated parameters when comparing the results in relation to the form of B. canis infection to B. gibsoni infection. Hematological indices showed significant differences between dogs infected with B. gibsoni and the complicated form of B. canis infection. In conclusion, the obtained results suggest differences in the changes of serum protein electrophoretic pattern between dogs infected with both Babesia species and thus, in the response to the infection caused by various Babesia parasites.
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spelling pubmed-76096562020-11-05 Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis Tóthová, Csilla Karasová, Martina Blaňarová, Lucia Fialkovičová, Mária Nagy, Oskar Sci Rep Article Canine babesiosis may cause several hematological and biochemical changes, but only limited studies are available regarding the possible differences of changes in animals infected by different Babesia parasites. The study focused on the evaluation of the differences in serum protein electrophoretic pattern between dogs naturally infected with B. gibsoni (17 dogs) and B. canis (40 dogs). The mean values of total proteins, β(1)-, β(2)- and γ-globulins were in dogs infected with B. gibsoni significantly higher (P < 0.05 and P < 0.001) than in dogs infected with B. canis. The relative concentrations of albumin, α(1)-, α(2)-globulins and the A/G ratios were in the B. gibsoni infected dogs significantly lower (P < 0.001), no significant differences were found in the relative concentrations of β(1)- and β(2)-globulins. Significant differences were found in most of the evaluated parameters when comparing the results in relation to the form of B. canis infection to B. gibsoni infection. Hematological indices showed significant differences between dogs infected with B. gibsoni and the complicated form of B. canis infection. In conclusion, the obtained results suggest differences in the changes of serum protein electrophoretic pattern between dogs infected with both Babesia species and thus, in the response to the infection caused by various Babesia parasites. Nature Publishing Group UK 2020-11-03 /pmc/articles/PMC7609656/ /pubmed/33144631 http://dx.doi.org/10.1038/s41598-020-75908-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tóthová, Csilla
Karasová, Martina
Blaňarová, Lucia
Fialkovičová, Mária
Nagy, Oskar
Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis
title Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis
title_full Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis
title_fullStr Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis
title_full_unstemmed Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis
title_short Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis
title_sort differences in serum protein electrophoretic pattern in dogs naturally infected with babesia gibsoni and babesia canis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609656/
https://www.ncbi.nlm.nih.gov/pubmed/33144631
http://dx.doi.org/10.1038/s41598-020-75908-7
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