The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s

The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary fibroblasts leads to induction of interferon-stimulated genes (ISGs) through JAK/STAT signaling. This effect is mainly attributed to MDA5 and...

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Detalles Bibliográficos
Autores principales: Tunbak, Hale, Enriquez-Gasca, Rocio, Tie, Christopher H. C., Gould, Poppy A., Mlcochova, Petra, Gupta, Ravindra K., Fernandes, Liane, Holt, James, van der Veen, Annemarthe G., Giampazolias, Evangelos, Burns, Kathleen H., Maillard, Pierre V., Rowe, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609715/
https://www.ncbi.nlm.nih.gov/pubmed/33144593
http://dx.doi.org/10.1038/s41467-020-19170-5

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