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The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System
Lung diseases are among the leading causes of morbidity and mortality. Complement activation may prevent a variety of respiratory infections, but on the other hand, could exacerbate tissue damage or contribute to adverse side effects. In this review, the associations of factors specific for compleme...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609860/ https://www.ncbi.nlm.nih.gov/pubmed/33193407 http://dx.doi.org/10.3389/fimmu.2020.585243 |
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author | Świerzko, Anna S. Cedzyński, Maciej |
author_facet | Świerzko, Anna S. Cedzyński, Maciej |
author_sort | Świerzko, Anna S. |
collection | PubMed |
description | Lung diseases are among the leading causes of morbidity and mortality. Complement activation may prevent a variety of respiratory infections, but on the other hand, could exacerbate tissue damage or contribute to adverse side effects. In this review, the associations of factors specific for complement activation via the lectin pathway (LP) with infections of the respiratory system, from birth to adulthood, are discussed. The most extensive data concern mannose-binding lectin (MBL) which together with other collectins (collectin-10, collectin-11) and the ficolins (ficolin-1, ficolin-2, ficolin-3) belong to pattern-recognition molecules (PRM) specific for the LP. Those PRM form complexes with MBL-associated serine proteases (MASP-1, MASP-2, MASP-3) and related non-enzymatic factors (MAp19, MAp44). Beside diseases affecting humanity for centuries like tuberculosis or neonatal pneumonia, some recently published data concerning COVID-19 are summarized. |
format | Online Article Text |
id | pubmed-7609860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76098602020-11-13 The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System Świerzko, Anna S. Cedzyński, Maciej Front Immunol Immunology Lung diseases are among the leading causes of morbidity and mortality. Complement activation may prevent a variety of respiratory infections, but on the other hand, could exacerbate tissue damage or contribute to adverse side effects. In this review, the associations of factors specific for complement activation via the lectin pathway (LP) with infections of the respiratory system, from birth to adulthood, are discussed. The most extensive data concern mannose-binding lectin (MBL) which together with other collectins (collectin-10, collectin-11) and the ficolins (ficolin-1, ficolin-2, ficolin-3) belong to pattern-recognition molecules (PRM) specific for the LP. Those PRM form complexes with MBL-associated serine proteases (MASP-1, MASP-2, MASP-3) and related non-enzymatic factors (MAp19, MAp44). Beside diseases affecting humanity for centuries like tuberculosis or neonatal pneumonia, some recently published data concerning COVID-19 are summarized. Frontiers Media S.A. 2020-10-21 /pmc/articles/PMC7609860/ /pubmed/33193407 http://dx.doi.org/10.3389/fimmu.2020.585243 Text en Copyright © 2020 Świerzko and Cedzyński http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Świerzko, Anna S. Cedzyński, Maciej The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System |
title | The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System |
title_full | The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System |
title_fullStr | The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System |
title_full_unstemmed | The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System |
title_short | The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System |
title_sort | influence of the lectin pathway of complement activation on infections of the respiratory system |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609860/ https://www.ncbi.nlm.nih.gov/pubmed/33193407 http://dx.doi.org/10.3389/fimmu.2020.585243 |
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