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Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas

The interplay between M. tuberculosis (Mtb) and humans is multifactorial. The susceptibility/resistance profile and the establishment of clinical tuberculosis (TB) still remains elusive. The gain-of-function variant rs10754558 in the NLRP3 gene (found in 30% of the world population) confers protecti...

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Detalles Bibliográficos
Autores principales:	Souza De Lima, Dhêmerson, Bomfim, Caio C. B., Leal, Vinícius N. C., Reis, Edione C., Soares, Jaíne L. S., Fernandes, Fernanda P., Amaral, Eduardo P., Loures, Flavio V., Ogusku, Mauricio M., Lima, Maria R. D'Imperio, Sadahiro, Aya, Pontillo, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609898/ https://www.ncbi.nlm.nih.gov/pubmed/33193317 http://dx.doi.org/10.3389/fimmu.2020.550624

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