Optical Coherence Tomography Angiography Findings in Long-Term Follow-up of Leber’s Hereditary Optic Neuropathy: Report of Two Cases

Leber’s hereditary optic neuropathy (LHON) is thought to be a neurovascular disease due to presence of vascular changes in asymptomatic patients. Here we present 2 patients in whom optical coherence tomography angiography (OCTA) imaging demonstrated capillary drop-out areas and decreased radial peri...

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Detalles Bibliográficos
Autores principales: Bingöl Kızıltunç, Pınar, Tüntaş Bilen, Feyza, Atilla, Huban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610057/
https://www.ncbi.nlm.nih.gov/pubmed/33342202
http://dx.doi.org/10.4274/tjo.galenos.2020.86300
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author Bingöl Kızıltunç, Pınar
Tüntaş Bilen, Feyza
Atilla, Huban
author_facet Bingöl Kızıltunç, Pınar
Tüntaş Bilen, Feyza
Atilla, Huban
author_sort Bingöl Kızıltunç, Pınar
collection PubMed
description Leber’s hereditary optic neuropathy (LHON) is thought to be a neurovascular disease due to presence of vascular changes in asymptomatic patients. Here we present 2 patients in whom optical coherence tomography angiography (OCTA) imaging demonstrated capillary drop-out areas and decreased radial peripapillary capillary (RPC) density in the quadrants that had thinner retinal nerve fiber layer (RNFL) in OCT images. Progressive decrease in RNFL and RPC density were shown in each patient at month 12 and 30 of follow-up. Following up patients with OCTA imaging in the future will provide insight into the pathogenesis and prognosis of LHON.
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spelling pubmed-76100572020-11-13 Optical Coherence Tomography Angiography Findings in Long-Term Follow-up of Leber’s Hereditary Optic Neuropathy: Report of Two Cases Bingöl Kızıltunç, Pınar Tüntaş Bilen, Feyza Atilla, Huban Turk J Ophthalmol Case Report Leber’s hereditary optic neuropathy (LHON) is thought to be a neurovascular disease due to presence of vascular changes in asymptomatic patients. Here we present 2 patients in whom optical coherence tomography angiography (OCTA) imaging demonstrated capillary drop-out areas and decreased radial peripapillary capillary (RPC) density in the quadrants that had thinner retinal nerve fiber layer (RNFL) in OCT images. Progressive decrease in RNFL and RPC density were shown in each patient at month 12 and 30 of follow-up. Following up patients with OCTA imaging in the future will provide insight into the pathogenesis and prognosis of LHON. Galenos Publishing 2020-10 2020-10-30 /pmc/articles/PMC7610057/ /pubmed/33342202 http://dx.doi.org/10.4274/tjo.galenos.2020.86300 Text en © Copyright 2020 by Turkish Ophthalmological Association | Turkish Journal of Ophthalmology, published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bingöl Kızıltunç, Pınar
Tüntaş Bilen, Feyza
Atilla, Huban
Optical Coherence Tomography Angiography Findings in Long-Term Follow-up of Leber’s Hereditary Optic Neuropathy: Report of Two Cases
title Optical Coherence Tomography Angiography Findings in Long-Term Follow-up of Leber’s Hereditary Optic Neuropathy: Report of Two Cases
title_full Optical Coherence Tomography Angiography Findings in Long-Term Follow-up of Leber’s Hereditary Optic Neuropathy: Report of Two Cases
title_fullStr Optical Coherence Tomography Angiography Findings in Long-Term Follow-up of Leber’s Hereditary Optic Neuropathy: Report of Two Cases
title_full_unstemmed Optical Coherence Tomography Angiography Findings in Long-Term Follow-up of Leber’s Hereditary Optic Neuropathy: Report of Two Cases
title_short Optical Coherence Tomography Angiography Findings in Long-Term Follow-up of Leber’s Hereditary Optic Neuropathy: Report of Two Cases
title_sort optical coherence tomography angiography findings in long-term follow-up of leber’s hereditary optic neuropathy: report of two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610057/
https://www.ncbi.nlm.nih.gov/pubmed/33342202
http://dx.doi.org/10.4274/tjo.galenos.2020.86300
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