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A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen
Fish collagen is one of the major allergens involved in fish allergies; however, it has not been well-established whether fish collagen can cause anaphylaxis among individuals with fish allergies, especially children. A 9-year-old girl experienced anaphylaxis after consuming 2 fruit-flavored gummy t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asia Pacific Association of Allergy, Asthma and Clinical Immunology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610083/ https://www.ncbi.nlm.nih.gov/pubmed/33178560 http://dx.doi.org/10.5415/apallergy.2020.10.e35 |
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author | Ueno, Rumi Takaoka, Yuri Shimojo, Naoshi Ohno, Fumiaki Yamaguchi, Tomohiro Matsunaga, Kayoko Kameda, Makoto |
author_facet | Ueno, Rumi Takaoka, Yuri Shimojo, Naoshi Ohno, Fumiaki Yamaguchi, Tomohiro Matsunaga, Kayoko Kameda, Makoto |
author_sort | Ueno, Rumi |
collection | PubMed |
description | Fish collagen is one of the major allergens involved in fish allergies; however, it has not been well-established whether fish collagen can cause anaphylaxis among individuals with fish allergies, especially children. A 9-year-old girl experienced anaphylaxis after consuming 2 fruit-flavored gummy tablets. Contacting the manufacturing company revealed that fish-derived collagen was used in the gummy tablets, and an oral fish collagen challenge test confirmed that the anaphylaxis was induced by fish collagen. Immunoblot analysis showed a 120-kDa band in a sample of the fish collagen in the gummy tablets, and no reactive band of the pork gelatin was observed. Additionally, salmon collagen and other fish samples that provoked symptoms were detected as a 120-kDa band in the immunoblot analysis. The 120-kDa band was identified as fish collagen by mass spectrometry confirming that it was the causative antigen of our patient's allergy. This case study confirms that fish collagen can cause anaphylaxis in children with fish allergies. Physicians and allergic individuals need to be aware that processed foods may contain fish collagen to avoid allergic reactions. |
format | Online Article Text |
id | pubmed-7610083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Asia Pacific Association of Allergy, Asthma and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-76100832020-11-10 A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen Ueno, Rumi Takaoka, Yuri Shimojo, Naoshi Ohno, Fumiaki Yamaguchi, Tomohiro Matsunaga, Kayoko Kameda, Makoto Asia Pac Allergy Case Report Fish collagen is one of the major allergens involved in fish allergies; however, it has not been well-established whether fish collagen can cause anaphylaxis among individuals with fish allergies, especially children. A 9-year-old girl experienced anaphylaxis after consuming 2 fruit-flavored gummy tablets. Contacting the manufacturing company revealed that fish-derived collagen was used in the gummy tablets, and an oral fish collagen challenge test confirmed that the anaphylaxis was induced by fish collagen. Immunoblot analysis showed a 120-kDa band in a sample of the fish collagen in the gummy tablets, and no reactive band of the pork gelatin was observed. Additionally, salmon collagen and other fish samples that provoked symptoms were detected as a 120-kDa band in the immunoblot analysis. The 120-kDa band was identified as fish collagen by mass spectrometry confirming that it was the causative antigen of our patient's allergy. This case study confirms that fish collagen can cause anaphylaxis in children with fish allergies. Physicians and allergic individuals need to be aware that processed foods may contain fish collagen to avoid allergic reactions. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2020-10-05 /pmc/articles/PMC7610083/ /pubmed/33178560 http://dx.doi.org/10.5415/apallergy.2020.10.e35 Text en Copyright © 2020. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Ueno, Rumi Takaoka, Yuri Shimojo, Naoshi Ohno, Fumiaki Yamaguchi, Tomohiro Matsunaga, Kayoko Kameda, Makoto A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen |
title | A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen |
title_full | A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen |
title_fullStr | A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen |
title_full_unstemmed | A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen |
title_short | A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen |
title_sort | case of pediatric anaphylaxis caused by gummy tablets containing fish collagen |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610083/ https://www.ncbi.nlm.nih.gov/pubmed/33178560 http://dx.doi.org/10.5415/apallergy.2020.10.e35 |
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