Cardioprotective effects of GLP‐1(28‐36a): A degraded metabolite or GLP‐1’s better half?

Molecular mechanism underlying glucagon‐like peptide‐1 exertion of cardioprotective effects in glucagon‐like peptide‐1 receptor‐dependent and ‐independent manners. Glucagon‐like peptide‐1 (28‐36a) enters coronary artery endothelial cells through macropinocytosis and binds to mitochondrial trifunctio...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yangyang, Kubota, Sodai, Iizuka, Katsumi, Yabe, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610112/
https://www.ncbi.nlm.nih.gov/pubmed/32428993
http://dx.doi.org/10.1111/jdi.13302
_version_ 1783605136242769920
author Liu, Yangyang
Kubota, Sodai
Iizuka, Katsumi
Yabe, Daisuke
author_facet Liu, Yangyang
Kubota, Sodai
Iizuka, Katsumi
Yabe, Daisuke
author_sort Liu, Yangyang
collection PubMed
description Molecular mechanism underlying glucagon‐like peptide‐1 exertion of cardioprotective effects in glucagon‐like peptide‐1 receptor‐dependent and ‐independent manners. Glucagon‐like peptide‐1 (28‐36a) enters coronary artery endothelial cells through macropinocytosis and binds to mitochondrial trifunctional protein‐α, shifting substrate utilization to increase adenosine triphosphate production and modulating a adenosine triphosphate‐sensor soluble adenylyl cyclase, thereby producing cyclic adenosine monophosphate and activating protein kinase A to exert cytoprotection from oxidative injury.[Image: see text]
format Online
Article
Text
id pubmed-7610112
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-76101122020-11-09 Cardioprotective effects of GLP‐1(28‐36a): A degraded metabolite or GLP‐1’s better half? Liu, Yangyang Kubota, Sodai Iizuka, Katsumi Yabe, Daisuke J Diabetes Investig Commentaries Molecular mechanism underlying glucagon‐like peptide‐1 exertion of cardioprotective effects in glucagon‐like peptide‐1 receptor‐dependent and ‐independent manners. Glucagon‐like peptide‐1 (28‐36a) enters coronary artery endothelial cells through macropinocytosis and binds to mitochondrial trifunctional protein‐α, shifting substrate utilization to increase adenosine triphosphate production and modulating a adenosine triphosphate‐sensor soluble adenylyl cyclase, thereby producing cyclic adenosine monophosphate and activating protein kinase A to exert cytoprotection from oxidative injury.[Image: see text] John Wiley and Sons Inc. 2020-06-24 2020-11 /pmc/articles/PMC7610112/ /pubmed/32428993 http://dx.doi.org/10.1111/jdi.13302 Text en © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Commentaries
Liu, Yangyang
Kubota, Sodai
Iizuka, Katsumi
Yabe, Daisuke
Cardioprotective effects of GLP‐1(28‐36a): A degraded metabolite or GLP‐1’s better half?
title Cardioprotective effects of GLP‐1(28‐36a): A degraded metabolite or GLP‐1’s better half?
title_full Cardioprotective effects of GLP‐1(28‐36a): A degraded metabolite or GLP‐1’s better half?
title_fullStr Cardioprotective effects of GLP‐1(28‐36a): A degraded metabolite or GLP‐1’s better half?
title_full_unstemmed Cardioprotective effects of GLP‐1(28‐36a): A degraded metabolite or GLP‐1’s better half?
title_short Cardioprotective effects of GLP‐1(28‐36a): A degraded metabolite or GLP‐1’s better half?
title_sort cardioprotective effects of glp‐1(28‐36a): a degraded metabolite or glp‐1’s better half?
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610112/
https://www.ncbi.nlm.nih.gov/pubmed/32428993
http://dx.doi.org/10.1111/jdi.13302
work_keys_str_mv AT liuyangyang cardioprotectiveeffectsofglp12836aadegradedmetaboliteorglp1sbetterhalf
AT kubotasodai cardioprotectiveeffectsofglp12836aadegradedmetaboliteorglp1sbetterhalf
AT iizukakatsumi cardioprotectiveeffectsofglp12836aadegradedmetaboliteorglp1sbetterhalf
AT yabedaisuke cardioprotectiveeffectsofglp12836aadegradedmetaboliteorglp1sbetterhalf

Ejemplares similares