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Statin‐induced autoimmune hepatitis in patients with type 1 diabetes: A report of two cases and literature review
Statins are widely used medications for the treatment of hypercholesterolemia, as well as prevention of cardiovascular disease. We report two patients with type 1 diabetes who developed autoimmune hepatitis after the administration of statin. The first patient developed the marked elevation of liver...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610114/ https://www.ncbi.nlm.nih.gov/pubmed/32277861 http://dx.doi.org/10.1111/jdi.13271 |
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author | Kawasaki, Eiji Fukuyama, Takahiro Kuriyama, Erisa Uchida, Aira Sagara, Yoko Tamai, Hidekazu Nakano, Yuko Tojikubo, Masayuki Koga, Nobuhiko |
author_facet | Kawasaki, Eiji Fukuyama, Takahiro Kuriyama, Erisa Uchida, Aira Sagara, Yoko Tamai, Hidekazu Nakano, Yuko Tojikubo, Masayuki Koga, Nobuhiko |
author_sort | Kawasaki, Eiji |
collection | PubMed |
description | Statins are widely used medications for the treatment of hypercholesterolemia, as well as prevention of cardiovascular disease. We report two patients with type 1 diabetes who developed autoimmune hepatitis after the administration of statin. The first patient developed the marked elevation of liver enzymes 6 months into atorvastatin therapy. The second patient developed liver dysfunction 8 months after the initiation of rosuvastatin therapy. Liver biopsies in both patients showed either portal, interface and lobular hepatitis or a piece‐meal necrosis with lymphocytes and plasma cell infiltration that were compatible with autoimmune hepatitis. Then, both patients were started on prednisolone, to which they responded well. Liver biopsy is to be considered for type 1 diabetes patients if there is no improvement of liver dysfunction after discontinuation of statins. |
format | Online Article Text |
id | pubmed-7610114 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76101142020-11-09 Statin‐induced autoimmune hepatitis in patients with type 1 diabetes: A report of two cases and literature review Kawasaki, Eiji Fukuyama, Takahiro Kuriyama, Erisa Uchida, Aira Sagara, Yoko Tamai, Hidekazu Nakano, Yuko Tojikubo, Masayuki Koga, Nobuhiko J Diabetes Investig Articles Statins are widely used medications for the treatment of hypercholesterolemia, as well as prevention of cardiovascular disease. We report two patients with type 1 diabetes who developed autoimmune hepatitis after the administration of statin. The first patient developed the marked elevation of liver enzymes 6 months into atorvastatin therapy. The second patient developed liver dysfunction 8 months after the initiation of rosuvastatin therapy. Liver biopsies in both patients showed either portal, interface and lobular hepatitis or a piece‐meal necrosis with lymphocytes and plasma cell infiltration that were compatible with autoimmune hepatitis. Then, both patients were started on prednisolone, to which they responded well. Liver biopsy is to be considered for type 1 diabetes patients if there is no improvement of liver dysfunction after discontinuation of statins. John Wiley and Sons Inc. 2020-05-16 2020-11 /pmc/articles/PMC7610114/ /pubmed/32277861 http://dx.doi.org/10.1111/jdi.13271 Text en © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Articles Kawasaki, Eiji Fukuyama, Takahiro Kuriyama, Erisa Uchida, Aira Sagara, Yoko Tamai, Hidekazu Nakano, Yuko Tojikubo, Masayuki Koga, Nobuhiko Statin‐induced autoimmune hepatitis in patients with type 1 diabetes: A report of two cases and literature review |
title | Statin‐induced autoimmune hepatitis in patients with type 1 diabetes: A report of two cases and literature review |
title_full | Statin‐induced autoimmune hepatitis in patients with type 1 diabetes: A report of two cases and literature review |
title_fullStr | Statin‐induced autoimmune hepatitis in patients with type 1 diabetes: A report of two cases and literature review |
title_full_unstemmed | Statin‐induced autoimmune hepatitis in patients with type 1 diabetes: A report of two cases and literature review |
title_short | Statin‐induced autoimmune hepatitis in patients with type 1 diabetes: A report of two cases and literature review |
title_sort | statin‐induced autoimmune hepatitis in patients with type 1 diabetes: a report of two cases and literature review |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610114/ https://www.ncbi.nlm.nih.gov/pubmed/32277861 http://dx.doi.org/10.1111/jdi.13271 |
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