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Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study
AIMS/INTRODUCTION: Low birthweight is reportedly associated with type 2 diabetes mellitus; however, this association has not been confirmed in the Japanese population, and whether high birthweight is associated with type 2 diabetes mellitus is controversial. We aimed to investigate the association b...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610122/ https://www.ncbi.nlm.nih.gov/pubmed/32298536 http://dx.doi.org/10.1111/jdi.13274 |
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author | Yokoyama, Maki Saito, Isao Ueno, Megumi Kato, Hiroaki Yoshida, Ayaka Kawamura, Ryoichi Maruyama, Koutatsu Takata, Yasunori Osawa, Haruhiko Tanigawa, Takeshi Sugiyama, Takashi |
author_facet | Yokoyama, Maki Saito, Isao Ueno, Megumi Kato, Hiroaki Yoshida, Ayaka Kawamura, Ryoichi Maruyama, Koutatsu Takata, Yasunori Osawa, Haruhiko Tanigawa, Takeshi Sugiyama, Takashi |
author_sort | Yokoyama, Maki |
collection | PubMed |
description | AIMS/INTRODUCTION: Low birthweight is reportedly associated with type 2 diabetes mellitus; however, this association has not been confirmed in the Japanese population, and whether high birthweight is associated with type 2 diabetes mellitus is controversial. We aimed to investigate the association between birthweight and type 2 diabetes mellitus among a general Japanese population. MATERIALS AND METHODS: Overall 1,135 middle‐ to old‐aged Japanese men and women were enrolled in the Toon Health Study. A 75‐g oral glucose tolerance test was used to diagnose type 2 diabetes mellitus, and a questionnaire survey about birthweight was administered. The association between birthweight and the prevalence of type 2 diabetes mellitus in later life of the participants was examined using multivariable logistic regression analysis. Stratified analysis by current body mass index was also carried out. RESULTS: The mean age was 56.5 ± 12.2 years. Type 2 diabetes mellitus was observed in 9.3% of the participants in this study. Compared with the reference group (2,500–3,999 g), the adjusted odds ratio of the low‐birthweight group (<2,500 g) for type 2 diabetes mellitus was 2.46 (95% confidence interval 1.48–4.10). The association between the high‐birthweight group (≥4000 g) and type 2 diabetes mellitus was not significant after including family history of diabetes in the multivariable model. The odds ratio of the low‐birthweight group for type 2 diabetes mellitus was higher in the overweight/obese group than in the non‐overweight group. CONCLUSIONS: Low birthweight was associated with an increased risk of type 2 diabetes mellitus in a Japanese population, especially in overweight/obese individuals. |
format | Online Article Text |
id | pubmed-7610122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76101222020-11-09 Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study Yokoyama, Maki Saito, Isao Ueno, Megumi Kato, Hiroaki Yoshida, Ayaka Kawamura, Ryoichi Maruyama, Koutatsu Takata, Yasunori Osawa, Haruhiko Tanigawa, Takeshi Sugiyama, Takashi J Diabetes Investig Articles AIMS/INTRODUCTION: Low birthweight is reportedly associated with type 2 diabetes mellitus; however, this association has not been confirmed in the Japanese population, and whether high birthweight is associated with type 2 diabetes mellitus is controversial. We aimed to investigate the association between birthweight and type 2 diabetes mellitus among a general Japanese population. MATERIALS AND METHODS: Overall 1,135 middle‐ to old‐aged Japanese men and women were enrolled in the Toon Health Study. A 75‐g oral glucose tolerance test was used to diagnose type 2 diabetes mellitus, and a questionnaire survey about birthweight was administered. The association between birthweight and the prevalence of type 2 diabetes mellitus in later life of the participants was examined using multivariable logistic regression analysis. Stratified analysis by current body mass index was also carried out. RESULTS: The mean age was 56.5 ± 12.2 years. Type 2 diabetes mellitus was observed in 9.3% of the participants in this study. Compared with the reference group (2,500–3,999 g), the adjusted odds ratio of the low‐birthweight group (<2,500 g) for type 2 diabetes mellitus was 2.46 (95% confidence interval 1.48–4.10). The association between the high‐birthweight group (≥4000 g) and type 2 diabetes mellitus was not significant after including family history of diabetes in the multivariable model. The odds ratio of the low‐birthweight group for type 2 diabetes mellitus was higher in the overweight/obese group than in the non‐overweight group. CONCLUSIONS: Low birthweight was associated with an increased risk of type 2 diabetes mellitus in a Japanese population, especially in overweight/obese individuals. John Wiley and Sons Inc. 2020-05-18 2020-11 /pmc/articles/PMC7610122/ /pubmed/32298536 http://dx.doi.org/10.1111/jdi.13274 Text en © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Articles Yokoyama, Maki Saito, Isao Ueno, Megumi Kato, Hiroaki Yoshida, Ayaka Kawamura, Ryoichi Maruyama, Koutatsu Takata, Yasunori Osawa, Haruhiko Tanigawa, Takeshi Sugiyama, Takashi Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study |
title | Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study |
title_full | Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study |
title_fullStr | Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study |
title_full_unstemmed | Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study |
title_short | Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study |
title_sort | low birthweight is associated with type 2 diabetes mellitus in japanese adults: the toon health study |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610122/ https://www.ncbi.nlm.nih.gov/pubmed/32298536 http://dx.doi.org/10.1111/jdi.13274 |
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