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Radiation Induced Multiple Skin Neoplasms Following Craniospinal Irradiation for Medulloblastoma. A Case Report

Patient: Female, 19-year-old Final Diagnosis: Dermatofibrosarcoma protruberans • hemangioendothelioma • malignant epithelial tumor • medulloblastoma Symptoms: Subcutaneous nodules • swelling • swelling in the thigh Medication: — Clinical Procedure: Biopsy • craniospinal radiation • surgical excision...

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Autores principales: Ali, Ahmed Amer Osman, Bayoumi, Yasser, Balbaid, Ali, Orz, Yasser, AlShakweer, Wafa, Eltawel, Mohamed Hussen, Tunio, Mutahir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610156/
https://www.ncbi.nlm.nih.gov/pubmed/33125361
http://dx.doi.org/10.12659/AJCR.917694
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author Ali, Ahmed Amer Osman
Bayoumi, Yasser
Balbaid, Ali
Orz, Yasser
AlShakweer, Wafa
Eltawel, Mohamed Hussen
Tunio, Mutahir
author_facet Ali, Ahmed Amer Osman
Bayoumi, Yasser
Balbaid, Ali
Orz, Yasser
AlShakweer, Wafa
Eltawel, Mohamed Hussen
Tunio, Mutahir
author_sort Ali, Ahmed Amer Osman
collection PubMed
description Patient: Female, 19-year-old Final Diagnosis: Dermatofibrosarcoma protruberans • hemangioendothelioma • malignant epithelial tumor • medulloblastoma Symptoms: Subcutaneous nodules • swelling • swelling in the thigh Medication: — Clinical Procedure: Biopsy • craniospinal radiation • surgical excision Specialty: Oncology OBJECTIVE: Unusual clinical course BACKGROUND: Following craniospinal irradiation in children with medulloblastoma, secondary neoplasms are among the most serious long-term sequelae that include leukemias and solid tumors of the urinary or digestive tracts, thyroid, skin, and central nervous system. Furthermore, in children with Gorlin syndrome following craniospinal irradiation for medulloblastoma, there is a rising incidence of skin and non-skin malignancies. CASE REPORT: The patient in the present study was a 19-year-old female who was treated with craniospinal irradiation and chemotherapy following gross total resection (GTR) for medulloblastoma at the age of 4 years. Fifteen years later, she developed a primary adnexal tumor at the medial aspect of her left thigh, glomangioma at the skin of her upper abdomen, dermatofibrosarcoma protruberans at the skin of her upper back, and Kaposiform hemangioendothelioma of the upper abdomen. All these tumors were successfully managed with radical resection without further adjuvant treatment. CONCLUSIONS: Metachronous of development of 4 histopathologically different skin tumors following craniospinal irradiation for medulloblastoma in long-term survivors has not previously been reported. The present case warrants a detailed dermatological periodic inspection in such patients.
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spelling pubmed-76101562020-11-04 Radiation Induced Multiple Skin Neoplasms Following Craniospinal Irradiation for Medulloblastoma. A Case Report Ali, Ahmed Amer Osman Bayoumi, Yasser Balbaid, Ali Orz, Yasser AlShakweer, Wafa Eltawel, Mohamed Hussen Tunio, Mutahir Am J Case Rep Articles Patient: Female, 19-year-old Final Diagnosis: Dermatofibrosarcoma protruberans • hemangioendothelioma • malignant epithelial tumor • medulloblastoma Symptoms: Subcutaneous nodules • swelling • swelling in the thigh Medication: — Clinical Procedure: Biopsy • craniospinal radiation • surgical excision Specialty: Oncology OBJECTIVE: Unusual clinical course BACKGROUND: Following craniospinal irradiation in children with medulloblastoma, secondary neoplasms are among the most serious long-term sequelae that include leukemias and solid tumors of the urinary or digestive tracts, thyroid, skin, and central nervous system. Furthermore, in children with Gorlin syndrome following craniospinal irradiation for medulloblastoma, there is a rising incidence of skin and non-skin malignancies. CASE REPORT: The patient in the present study was a 19-year-old female who was treated with craniospinal irradiation and chemotherapy following gross total resection (GTR) for medulloblastoma at the age of 4 years. Fifteen years later, she developed a primary adnexal tumor at the medial aspect of her left thigh, glomangioma at the skin of her upper abdomen, dermatofibrosarcoma protruberans at the skin of her upper back, and Kaposiform hemangioendothelioma of the upper abdomen. All these tumors were successfully managed with radical resection without further adjuvant treatment. CONCLUSIONS: Metachronous of development of 4 histopathologically different skin tumors following craniospinal irradiation for medulloblastoma in long-term survivors has not previously been reported. The present case warrants a detailed dermatological periodic inspection in such patients. International Scientific Literature, Inc. 2020-10-30 /pmc/articles/PMC7610156/ /pubmed/33125361 http://dx.doi.org/10.12659/AJCR.917694 Text en © Am J Case Rep, 2020 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Ali, Ahmed Amer Osman
Bayoumi, Yasser
Balbaid, Ali
Orz, Yasser
AlShakweer, Wafa
Eltawel, Mohamed Hussen
Tunio, Mutahir
Radiation Induced Multiple Skin Neoplasms Following Craniospinal Irradiation for Medulloblastoma. A Case Report
title Radiation Induced Multiple Skin Neoplasms Following Craniospinal Irradiation for Medulloblastoma. A Case Report
title_full Radiation Induced Multiple Skin Neoplasms Following Craniospinal Irradiation for Medulloblastoma. A Case Report
title_fullStr Radiation Induced Multiple Skin Neoplasms Following Craniospinal Irradiation for Medulloblastoma. A Case Report
title_full_unstemmed Radiation Induced Multiple Skin Neoplasms Following Craniospinal Irradiation for Medulloblastoma. A Case Report
title_short Radiation Induced Multiple Skin Neoplasms Following Craniospinal Irradiation for Medulloblastoma. A Case Report
title_sort radiation induced multiple skin neoplasms following craniospinal irradiation for medulloblastoma. a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610156/
https://www.ncbi.nlm.nih.gov/pubmed/33125361
http://dx.doi.org/10.12659/AJCR.917694
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