Role of RASA1 in cancer: A review and update

Ras p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis. As a result, RASA1 also contributes to pathological processes in vascular diseases and tumour formation. This review focu...

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Detalles Bibliográficos
Autores principales: Zhang, Yanhua, Li, Yue, Wang, Quanyue, Su, Bo, Xu, Hui, Sun, Yang, Sun, Pei, Li, Rumeng, Peng, Xiaochun, Cai, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610306/
https://www.ncbi.nlm.nih.gov/pubmed/33125148
http://dx.doi.org/10.3892/or.2020.7807
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author Zhang, Yanhua
Li, Yue
Wang, Quanyue
Su, Bo
Xu, Hui
Sun, Yang
Sun, Pei
Li, Rumeng
Peng, Xiaochun
Cai, Jun
author_facet Zhang, Yanhua
Li, Yue
Wang, Quanyue
Su, Bo
Xu, Hui
Sun, Yang
Sun, Pei
Li, Rumeng
Peng, Xiaochun
Cai, Jun
author_sort Zhang, Yanhua
collection PubMed
description Ras p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis. As a result, RASA1 also contributes to pathological processes in vascular diseases and tumour formation. This review focuses on the role of RASA1 in multiple tumours types in the lung, intestines, liver, and breast. Furthermore, we discuss the potential mechanisms of RASA1 and its downstream effects through Ras/RAF/MEK/ERK or Ras/PI3K/AKT signalling. Moreover, miRNAs are capable of regulating RASA1 and could be a novel targeted treatment strategy for tumours.
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spelling pubmed-76103062020-11-04 Role of RASA1 in cancer: A review and update Zhang, Yanhua Li, Yue Wang, Quanyue Su, Bo Xu, Hui Sun, Yang Sun, Pei Li, Rumeng Peng, Xiaochun Cai, Jun Oncol Rep Review Ras p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis. As a result, RASA1 also contributes to pathological processes in vascular diseases and tumour formation. This review focuses on the role of RASA1 in multiple tumours types in the lung, intestines, liver, and breast. Furthermore, we discuss the potential mechanisms of RASA1 and its downstream effects through Ras/RAF/MEK/ERK or Ras/PI3K/AKT signalling. Moreover, miRNAs are capable of regulating RASA1 and could be a novel targeted treatment strategy for tumours. D.A. Spandidos 2020-12 2020-10-13 /pmc/articles/PMC7610306/ /pubmed/33125148 http://dx.doi.org/10.3892/or.2020.7807 Text en Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Zhang, Yanhua
Li, Yue
Wang, Quanyue
Su, Bo
Xu, Hui
Sun, Yang
Sun, Pei
Li, Rumeng
Peng, Xiaochun
Cai, Jun
Role of RASA1 in cancer: A review and update
title Role of RASA1 in cancer: A review and update
title_full Role of RASA1 in cancer: A review and update
title_fullStr Role of RASA1 in cancer: A review and update
title_full_unstemmed Role of RASA1 in cancer: A review and update
title_short Role of RASA1 in cancer: A review and update
title_sort role of rasa1 in cancer: a review and update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610306/
https://www.ncbi.nlm.nih.gov/pubmed/33125148
http://dx.doi.org/10.3892/or.2020.7807
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