STEEP mediates STING ER exit and activation of signaling

STING is essential for control of infections and for tumor immunosurveillance, but can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER), and traffics following stimulation to ERGIC/Golgi where signaling occurs. Although STING ER exit is the rate-limiting step in...

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Detalles Bibliográficos
Autores principales: Zhang, Bao-cun, Nandakumar, Ramya, Reinert, Line S, Huang, Jinrong, Laustsen, Anders, Gao, Zong-liang, Sun, Cheng-long, Jensen, Søren Beck, Troldborg, Anne, Assil, Sonia, Berthelsen, Martin F., Scavenius, Carsten, Zhang, Yan, Windross, Samuel J, Olagnier, David, Prabakaran, Thaneas, Bodda, Chiranjeevi, Narita, Ryo, Cai, Yujia, Zhang, Cong-gang, Stenmark, Harald, Doucet, Christine M, Noda, Takeshi, Guo, Zheng, Goldbach-Mansky, Raphaela, Hartmann, Rune, Chen, Zhijian J, Enghild, Jan J, Bak, Rasmus O, Thomsen, Martin K., Paludan, Søren R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610351/
https://www.ncbi.nlm.nih.gov/pubmed/32690950
http://dx.doi.org/10.1038/s41590-020-0730-5

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