WAPL maintains a cohesin loading cycle to preserve cell-type specific distal gene regulation

The cohesin complex plays an essential role in maintaining genome organization. However, its role in gene regulation remains largely unresolved. Here, we report that the cohesin release factor WAPL creates a pool of free cohesin, in a process known as cohesin turnover, which reloads it to cell-type...

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Detalles Bibliográficos
Autores principales: Liu, Ning Qing, Maresca, Michela, van den Brand, Teun, Braccioli, Luca, Schijns, Marijne M.G.A., Teunissen, Hans, Bruneau, Benoit G., Nora, Elphège P., de Wit, Elzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610352/
https://www.ncbi.nlm.nih.gov/pubmed/33318687
http://dx.doi.org/10.1038/s41588-020-00744-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610352/
https://www.ncbi.nlm.nih.gov/pubmed/33318687
http://dx.doi.org/10.1038/s41588-020-00744-4

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