Vav2 Pharmaco-Mimetic Mice Reveal the Therapeutic Value and Caveats of the Catalytic Inactivation of a Rho Exchange Factor

The current paradigm holds that the inhibition of Rho guanosine nucleotide exchange factors (GEFs), the enzymes that stimulate Rho GTPases, can be a valuable therapeutic strategy to treat Rho-dependent tumors. However, formal validation of this idea using in vivo models is still missing. In this con...

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Detalles Bibliográficos
Autores principales: Lorenzo-Martín, L. Francisco, Rodríguez-Fdez, Sonia, Fabbiano, Salvatore, Abad, Antonio, García-Macías, María C., Dosil, Mercedes, Cuadrado, Myriam, Robles-Valero, Javier, Bustelo, Xosé R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610363/
https://www.ncbi.nlm.nih.gov/pubmed/32528129
http://dx.doi.org/10.1038/s41388-020-1353-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610363/
https://www.ncbi.nlm.nih.gov/pubmed/32528129
http://dx.doi.org/10.1038/s41388-020-1353-x

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