Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

The kinetochore is a macromolecular structure that assembles on the centromeres of chromosomes and provides the major attachment point for spindle microtubules during mitosis. In Trypanosoma brucei the proteins that make up the kinetochore are highly divergent, with the inner kinetochore comprising...

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Detalles Bibliográficos
Autores principales: Saldivia, Manuel, Fang, Eric, Ma, Xiaolei, Myburgh, Elmarie, Carnielli, Juliana B. T., Bower-Lepts, Christopher, Brown, Elaine, Ritchie, Ryan, Lakshminarayana, Suresh B., Chen, Yen-Liang, Patra, Debjani, Ornelas, Elizabeth, Koh, Hazel X. Y., Williams, Sarah, Supek, Frantisek, Paape, Daniel, McCulloch, Richard, Kaiser, Marcel, Barrett, Michael P., Jiricek, Jan, Diagana, Thierry T., Mottram, Jeremy C., Rao, Srinivasa P.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610364/
https://www.ncbi.nlm.nih.gov/pubmed/32661312
http://dx.doi.org/10.1038/s41564-020-0745-6

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