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Single-cell analysis of clonal maintenance of transcriptional and epigenetic states in cancer cells

Propagation of clonal regulatory programs contributes to cancer development. It is poorly understood how epigenetic mechanisms interact with genetic drivers to shape this process. Here we combine single-cell analysis of transcription and DNA methylation with a Luria-Delbrück experimental design to d...

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Detalles Bibliográficos
Autores principales:	Meir, Zohar, Mukamel, Zohar, Chomsky, Elad, Lifshitz, Aviezer, Tanay, Amos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610382/ https://www.ncbi.nlm.nih.gov/pubmed/32601473 http://dx.doi.org/10.1038/s41588-020-0645-y

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