PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia

Mutant KRAS modulates the metabolic plasticity of cancer cells conferring growth advantage during hypoxia, but the molecular underpinnings are largely unknown. Using a lipidomic screen, we found that PLCγ1 is suppressed during hypoxia in KRAS-mutant human lung adenocarcinoma cancer cell lines. Suppr...

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Detalles Bibliográficos
Autores principales: Saliakoura, Maria, Sebastiano, Matteo Rossi, Pozzato, Chiara, Heidel, Florian H., Schnöder, Tina M., Prince, Spasenija Savic, Bubendorf, Lukas, Pinton, Paolo, Schmid, Ralph, Baumgartner, Johanna, Freigang, Stefan, Berezowska, Sabina A., Rimessi, Alessandro, Konstantinidou, Georgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610419/
https://www.ncbi.nlm.nih.gov/pubmed/33077911
http://dx.doi.org/10.1038/s41556-020-00592-8

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