Cargando…

Ultra-Low DNA Input into Whole Genome Methylation Assays and Detection of Oncogenic Methylation and Copy Number Variants in Circulating Tumour DNA

Background: Abnormal CpG methylation in cancer is ubiquitous and generally detected in tumour specimens using a variety of techniques at a resolution encompassing single CpG loci to genome wide coverage. Analysis of samples with very low DNA inputs, such as formalin fixed (FFPE) biopsy specimens fro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Whalley, Celina, Payne, Karl, Domingo, Enric, Blake, Andrew, Richman, Susan, Brooks, Jill, Batis, Nikolaos, Spruce, Rachel, Mehanna, Hisham, Nankivell, Paul, Beggs, Andrew D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610445/ https://www.ncbi.nlm.nih.gov/pubmed/33777442 http://dx.doi.org/10.3390/epigenomes5010006

Ejemplares similares

Circulating Tumour Cell Biomarkers in Head and Neck Cancer: Current Progress and Future Prospects
por: Payne, Karl, et al.
Publicado: (2019)

Characterizing the epithelial–mesenchymal transition status of circulating tumor cells in head and neck squamous cell carcinoma
por: Payne, Karl, et al.
Publicado: (2022)

Lack of predictive tools for conventional and targeted cancer therapy: Barriers to biomarker development and clinical translation()
por: Batis, Nikolaos, et al.
Publicado: (2021)

Circulating Tumour Cell Expression of Immune Markers as Prognostic and Therapeutic Biomarkers in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
por: Payne, Karl, et al.
Publicado: (2020)

Immediate Sample Fixation Increases Circulating Tumour Cell (CTC) Capture and Preserves Phenotype in Head and Neck Squamous Cell Carcinoma: Towards a Standardised Approach to Microfluidic CTC Biomarker Discovery
por: Payne, Karl, et al.
Publicado: (2021)

Feasibility of mass cytometry proteomic characterisation of circulating tumour cells in head and neck squamous cell carcinoma for deep phenotyping
por: Payne, Karl, et al.
Publicado: (2023)

The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review
por: Fussey, Jonathan M., et al.
Publicado: (2018)

The impact of low input DNA on the reliability of DNA methylation as measured by the Illumina Infinium MethylationEPIC BeadChip
por: Watkins, Sarah Holmes, et al.
Publicado: (2022)

Using high-density DNA methylation arrays to profile copy number alterations
por: Feber, Andrew, et al.
Publicado: (2014)

Ribosomal DNA Copy Number Variation is Coupled with DNA Methylation Changes at the 45S rDNA Locus
por: Razzaq, Aleem, et al.
Publicado: (2023)

Copy number-dependent DNA methylation of the Pyricularia oryzae MAGGY retrotransposon is triggered by DNA damage
por: Van Vu, Ba, et al.
Publicado: (2021)

Colorimetric detection of both total genomic and loci-specific DNA methylation from limited DNA inputs
por: Wee, Eugene J. H., et al.
Publicado: (2015)

Regulation of Canonical Oncogenic Signaling Pathways in Cancer via DNA Methylation
por: Lu, Jennifer, et al.
Publicado: (2020)

Human Papillomavirus (HPV) Vaccine Effectiveness and Potential Herd Immunity for Reducing Oncogenic Oropharyngeal HPV-16 Prevalence in the United Kingdom: A Cross-sectional Study
por: Mehanna, Hisham, et al.
Publicado: (2019)

DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma
por: Haider, Zahra, et al.
Publicado: (2020)

Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma
por: Bryant, Jennifer, et al.
Publicado: (2019)

Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny
por: Lee, W, et al.
Publicado: (2015)

Latest techniques to study DNA methylation
por: Gouil, Quentin, et al.
Publicado: (2019)

Methylation of DNA
por: Gold, Marvin, et al.
Publicado: (1966)

DNA Methylation Patterns in Normal Tissue Correlate more Strongly with Breast Cancer Status than Copy-Number Variants
por: Gao, Yang, et al.
Publicado: (2018)

DNA methylation and DNA methyltransferases
por: Edwards, John R., et al.
Publicado: (2017)

Copy number alterations in urothelial carcinomas: their clinicopathological significance and correlation with DNA methylation alterations
por: Nishiyama, Naotaka, et al.
Publicado: (2011)

The association between copy number aberration, DNA methylation and gene expression in tumor samples
por: Sun, Wei, et al.
Publicado: (2018)

Detection of rare mutations, copy number alterations, and methylation in the same template DNA molecules
por: Wang, Yuxuan, et al.
Publicado: (2023)

The anti-tumour activity of DNA methylation inhibitor 5-aza-2′-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress
por: Gleneadie, Hannah J., et al.
Publicado: (2021)

Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A
por: Kelly, Richard D. W., et al.
Publicado: (2012)

Upper Aerodigestive Tract Squamous Cell Carcinomas Show Distinct Overall DNA Methylation Profiles and Different Molecular Mechanisms behind WNT Signaling Disruption
por: Soares-Lima, Sheila Coelho, et al.
Publicado: (2021)

Feasibility of recruitment to an oral dysplasia trial in the United Kingdom
por: Nankivell, Paul, et al.
Publicado: (2012)

DNA methylation analyses of urothelial carcinoma reveal distinct epigenetic subtypes and an association between gene copy number and methylation status
por: Lauss, Martin, et al.
Publicado: (2012)

Integrative analysis of DNA copy number, DNA methylation and gene expression in multiple myeloma reveals alterations related to relapse
por: Krzeminski, Patryk, et al.
Publicado: (2016)

Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs
por: Castellani, Christina A., et al.
Publicado: (2020)

DNA methylation in cancer: three decades of discovery
por: Feinberg, Andrew
Publicado: (2014)

DNA Methylation: Insights into Human Evolution
por: Hernando-Herraez, Irene, et al.
Publicado: (2015)

Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance
por: Ganapathi, S K, et al.
Publicado: (2014)

Methylation changes in the TFAP2E promoter region are associated with BRAF mutation and poorer overall & disease free survival in colorectal cancer
por: Beggs, Andrew D., et al.
Publicado: (2015)

DNA Methylation and Schizophrenia: Current Literature and Future Perspective
por: Magwai, Thabo, et al.
Publicado: (2021)

DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer
por: Board, Ruth E, et al.
Publicado: (2008)

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience
por: Capper, David, et al.
Publicado: (2018)

Methylation of mitochondrial DNA displacement loop region regulates mitochondrial copy number in colorectal cancer
por: Tong, Huan, et al.
Publicado: (2017)

Mitochondrial DNA methylation and copy number predict body composition in a young female population
por: Bordoni, Laura, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_dcj09tpe7d5p0097p5oa8m682l