Selective Mediator-dependence of cell type-specifying transcription

The Mediator complex directs signals from DNA-binding transcription factors to RNA polymerase (Pol) II. Despite this pivotal position, mechanistic understanding of Mediator in human cells remains incomplete. Here, we quantified Mediator-controlled Pol II kinetics by coupling rapid subunit degradatio...

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Detalles Bibliográficos
Autores principales: Jaeger, Martin G., Schwalb, Björn, Mackowiak, Sebastian D., Velychko, Taras, Hanzl, Alexander, Imrichova, Hana, Brand, Matthias, Agerer, Benedikt, Chorn, Someth, Nabet, Behnam, Ferguson, Fleur M., Müller, André C., Bergthaler, Andreas, Gray, Nathanael S., Bradner, James E., Bock, Christoph, Hnisz, Denes, Cramer, Patrick, Winter, Georg E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610447/
https://www.ncbi.nlm.nih.gov/pubmed/32483291
http://dx.doi.org/10.1038/s41588-020-0635-0

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