Cargando…

Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes

Follicular helper T cells (Tfh) are implicated in type 1 diabetes (T1D) and their development has been linked to CD28 costimulation. We tested whether Tfh were decreased by costimulation blockade using the CTLA-4-Ig fusion protein (Abatacept) in a mouse model of diabetes and in individuals with new...

Descripción completa

Detalles Bibliográficos
Autores principales:	Edner, Natalie M., Heuts, Frank, Thomas, Niclas, Wang, Chun Jing, Petersone, Lina, Kenefeck, Rupert, Kogimtzis, Alexandros, Ovcinnikovs, Vitalijs, Ross, Ellen M., Ntavli, Elisavet, Elfaki, Yassin, Eichmann, Martin, Baptista, Roman, Ambery, Philip, Jermutus, Lutz, Peakman, Mark, Rosenthal, Miranda, Walker, Lucy S.K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610476/ https://www.ncbi.nlm.nih.gov/pubmed/32747817 http://dx.doi.org/10.1038/s41590-020-0744-z

Ejemplares similares

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity
por: Wang, Chun Jing, et al.
Publicado: (2022)

Author Correction: Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity
por: Wang, Chun Jing, et al.
Publicado: (2023)

T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship
por: Petersone, Lina, et al.
Publicado: (2018)

Stratification of PD-1 blockade response in melanoma using pre- and post-treatment immunophenotyping of peripheral blood
por: Edner, Natalie M, et al.
Publicado: (2023)

IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation
por: Petersone, Lina, et al.
Publicado: (2023)

Predicting clinical response to costimulation blockade in autoimmunity
por: Edner, Natalie M, et al.
Publicado: (2020)

The Aryl Hydrocarbon Receptor: Differential Contribution to T Helper 17 and T Cytotoxic 17 Cell Development
por: Hayes, Mark D., et al.
Publicado: (2014)

CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo
por: Langenhorst, Daniela, et al.
Publicado: (2018)

Follicular Helper CD4(+) T Cells, Follicular Regulatory CD4(+) T Cells, and Inducible Costimulator and Their Roles in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
por: Zhang, Xue, et al.
Publicado: (2021)

Inducible Costimulator Protein (Icos) Controls T Helper Cell Subset Polarization after Virus and Parasite Infection
por: Kopf, Manfred, et al.
Publicado: (2000)

CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4
Publicado: (1993)

Glucagon and exenatide improve contractile recovery following ischaemia/reperfusion in the isolated perfused rat heart
por: Lindsay, Ross T., et al.
Publicado: (2023)

CD28-independent Induction of T Helper Cells and Immunoglobulin Class Switches Requires Costimulation by the Heat-stable Antigen
por: Wu, Yan, et al.
Publicado: (1998)

ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells
por: Panneton, Vincent, et al.
Publicado: (2023)

New battlefields for costimulation
por: Martin-Orozco, Natalia, et al.
Publicado: (2006)

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation
Publicado: (1994)

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines
Publicado: (1996)

CD28, Costimulator or Agonist Receptor?
por: Margulies, David H.
Publicado: (2003)

A Proteomic View at T Cell Costimulation
por: Lichtenfels, Rudolf, et al.
Publicado: (2012)

Costimulation Blockade in Kidney Transplantation: An Update
por: Malvezzi, Paolo, et al.
Publicado: (2016)

Costimulation Blockade in Vascularized Composite Allotransplantation
por: Giannis, Dimitrios, et al.
Publicado: (2020)

Costimulation Blockade in Kidney Transplant Recipients
por: van der Zwan, Marieke, et al.
Publicado: (2019)

Two pathways of costimulation through CD28
por: Miller, Jim, et al.
Publicado: (2009)

Costimulation blockade and Tregs in solid organ transplantation
por: Muckenhuber, Moritz, et al.
Publicado: (2022)

A pathway of costimulation that prevents anergy in CD28- T cells: B7- independent costimulation of CD1-restricted T cells
Publicado: (1995)

Inducible T-Cell Costimulator Ligand Plays a Dual Role in Melanoma Metastasis upon Binding to Osteopontin or Inducible T-Cell Costimulator
por: Raineri, Davide, et al.
Publicado: (2021)

Effects of Cotadutide on Metabolic and Hepatic Parameters in Adults With Overweight or Obesity and Type 2 Diabetes: A 54-Week Randomized Phase 2b Study
por: Nahra, Rajaa, et al.
Publicado: (2021)

Role of Interleukin 12 and Costimulators in T Cell Anergy In Vivo
por: Parijs, Luk Van, et al.
Publicado: (1997)

CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia
por: Harris, Nicola, et al.
Publicado: (1997)

Role of interleukin 12 and costimulators in T cell anergy in vivo
por: Van Parijs, Luk, et al.
Publicado: (2009)

T cell exhaustion, costimulation and clinical outcome in autoimmunity and infection
por: McKinney, Eoin F., et al.
Publicado: (2015)

The Role of Costimulation Blockade in Solid Organ and Islet Xenotransplantation
por: Samy, Kannan P., et al.
Publicado: (2017)

Tumor-targeted costimulation by using bi-specific aptamers
por: Pastor, Fernando
Publicado: (2016)

Reduction in CD4 Central Memory T-Cell Subset in Costimulation Modulator Abatacept-Treated Patients With Recent-Onset Type 1 Diabetes Is Associated With Slower C-Peptide Decline
por: Orban, Tihamer, et al.
Publicado: (2014)

Life of T Follicular Helper Cells
por: Suh, Woong-Kyung
Publicado: (2015)

Costimulation through B7-2 (CD86) Is Required for the Induction of a Lung Mucosal T Helper Cell 2 (TH2) Immune Response and Altered Airway Responsiveness
por: Tsuyuki, Shogo, et al.
Publicado: (1997)

Hospital admissions for severe infections in people with chronic kidney disease in relation to renal disease severity and diabetes status
por: Berni, Ellen, et al.
Publicado: (2018)

Costimulation Modulation With Abatacept in Patients With Recent-Onset Type 1 Diabetes: Follow-up 1 Year After Cessation of Treatment
por: Orban, Tihamer, et al.
Publicado: (2014)

Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases
por: Yoshitomi, Hiroyuki, et al.
Publicado: (2020)

Modulation of LIGHT-HVEM Costimulation Prolongs Cardiac Allograft Survival
por: Ye, Qunrui, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_qk50g85209thnh46n4m8f486f9