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DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
Certain mutagens, including the APOBEC3 (A3) cytosine deaminase enzymes, can create multiple genetic changes in a single event. Activity of A3s results in striking ‘mutation showers’ occurring near DNA breakpoints, however less is known about mechanisms underlying the majority of A3 mutations. We cl...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610516/ https://www.ncbi.nlm.nih.gov/pubmed/32747826 http://dx.doi.org/10.1038/s41588-020-0674-6 |