Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ (IFN-γ) or interleukin-17 (IL-17) have intrinsically distinct metabolic requirements. Whereas IFN-γ(+) γδ T cells were a...

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Detalles Bibliográficos
Autores principales: Lopes, Noella, McIntyre, Claire, Martin, Stefania, Raverdeau, Mathilde, Sumaria, Nital, Kohlgruber, Ayano C., Fiala, Gina J., Agudelo, Leandro, Dyck, Lydia, Kane, Harry, Douglas, Aaron, Cunningham, Stephen, Prendeville, Hannah, Loftus, Roisin, Carmody, Colleen, Pierre, Philippe, Kellis, Manolis, Brenner, Michael, Argüello, Rafael J., Silva-Santos, Bruno, Pennington, Daniel J., Lynch, Lydia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610600/
https://www.ncbi.nlm.nih.gov/pubmed/33462452
http://dx.doi.org/10.1038/s41590-020-00848-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610600/
https://www.ncbi.nlm.nih.gov/pubmed/33462452
http://dx.doi.org/10.1038/s41590-020-00848-3

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