Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states

RNA polymerase III (Pol III) synthesises tRNAs and other short, essential RNAs. Human Pol III misregulation is linked to tumour transformation, neurodegenerative and developmental disorders, and increased sensitivity to viral infections. Here, we present cryo-EM structures at 2.8 to 3.3 Å resolution...

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Detalles Bibliográficos
Autores principales: Girbig, Mathias, Misiaszek, Agata D., Vorländer, Matthias K., Lafita, Aleix, Grötsch, Helga, Baudin, Florence, Bateman, Alex, Müller, Christoph W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610652/
https://www.ncbi.nlm.nih.gov/pubmed/33558764
http://dx.doi.org/10.1038/s41594-020-00555-5

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