Cargando…

Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin

Characterization of the progression of cellular states during human embryogenesis can provide insights into the origin of pediatric diseases. We examined the transcriptional states of neural crest- and mesoderm-derived lineages differentiating into adrenal glands, kidneys, endothelium, and hematopoi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kameneva, Polina, Artemov, Artem V., Kastriti, Maria Eleni, Faure, Louis, Olsen, Thale K., Otte, Jörg, Erickson, Alek, Semsch, Bettina, Andersson, Emma R., Ratz, Michael, Frisen, Jonas, Tischler, Arthur S., de Krijger, Ronald R., Bouderlique, Thibault, Akkuratova, Natalia, Vorontsova, Maria, Gusev, Oleg, Fried, Kaj, Sundstrom, Erik, Mei, Shenglin, Kogner, Per, Baryawno, Ninib, Kharchenko, Peter V., Adameyko, Igor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610777/ https://www.ncbi.nlm.nih.gov/pubmed/33833454 http://dx.doi.org/10.1038/s41588-021-00818-x

Ejemplares similares

Developmental heterogeneity of embryonic neuroendocrine chromaffin cells and their maturation dynamics
por: Akkuratova, Natalia, et al.
Publicado: (2022)

The immune cell atlas of human neuroblastoma
por: Verhoeven, Bronte Manouk, et al.
Publicado: (2022)

Neuronal lineages derived from the nerve-associated Schwann cell precursors
por: Kameneva, Polina, et al.
Publicado: (2020)

The transcriptional portraits of the neural crest at the individual cell level
por: Erickson, Alek G., et al.
Publicado: (2023)

High Expression of PPM1D Induces Tumors Phenotypically Similar to TP53 Loss-of-Function Mutations in Mice
por: Milosevic, Jelena, et al.
Publicado: (2021)

Embryonic sympathoblasts transiently express TrkB in vivo and proliferate in response to brain-derived neurotrophic factor in vitro
por: Straub, Jennifer A, et al.
Publicado: (2007)

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma
por: Olsen, Thale Kristin, et al.
Publicado: (2022)

MDB-04. SINGLE-CELL TRANSCRIPTOMIC ANALYSIS REVEALS DISTINCT GENOMIC LANDSCAPES, CELL TRAJECTORIES, AND TUMOUR-MICROENVIRONMENT INTERACTIONS IN FOUR SUBTYPES OF MEDULLOBLASTOMA
por: Ruchiy, Yana, et al.
Publicado: (2023)

Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish
por: Xie, Meng, et al.
Publicado: (2019)

dropEst: pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments
por: Petukhov, Viktor, et al.
Publicado: (2018)

Recent Advances in Single-Cell RNA-Sequencing of Primary and Metastatic Clear Cell Renal Cell Carcinoma
por: Alchahin, Adele M., et al.
Publicado: (2023)

Is human cytomegalovirus a target in cancer therapy?
por: Johnsen, John Inge, et al.
Publicado: (2011)

STRA6 is essential for induction of vascular smooth muscle lineages in human embryonic cardiac outflow tract development
por: Zhou, Chikai, et al.
Publicado: (2023)

Schwann cell precursors represent a neural crest‐like state with biased multipotency
por: Kastriti, Maria Eleni, et al.
Publicado: (2022)

Schwann Cell Precursors Generate the Majority of Chromaffin Cells in Zuckerkandl Organ and Some Sympathetic Neurons in Paraganglia
por: Kastriti, Maria Eleni, et al.
Publicado: (2019)

Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges
por: Kaucka, Marketa, et al.
Publicado: (2021)

Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance
por: Wickström, Malin, et al.
Publicado: (2015)

A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma
por: Alchahin, Adele M., et al.
Publicado: (2022)

Serotonin limits generation of chromaffin cells during adrenal organ development
por: Kameneva, Polina, et al.
Publicado: (2022)

The Nervous System Orchestrates and Integrates Craniofacial Development: A Review
por: Adameyko, Igor, et al.
Publicado: (2016)

Directionality of developing skeletal muscles is set by mechanical forces
por: Sunadome, Kazunori, et al.
Publicado: (2023)

Heterogeneity and Developmental Connections between Cell Types Inhabiting Teeth
por: Krivanek, Jan, et al.
Publicado: (2017)

Error-prone bypass of DNA lesions during lagging strand replication is a common source of germline and cancer mutations
por: Seplyarskiy, Vladimir B., et al.
Publicado: (2018)

Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses
por: Hirz, Taghreed, et al.
Publicado: (2023)

scFates: a scalable python package for advanced pseudotime and bifurcation analysis from single-cell data
por: Faure, Louis, et al.
Publicado: (2022)

Plasticity of Dental Cell Types in Development, Regeneration, and Evolution
por: Krivanek, J., et al.
Publicado: (2023)

Macrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy
por: Valind, Anders, et al.
Publicado: (2023)

A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology
por: Petersen, Julian, et al.
Publicado: (2023)

Author Correction: A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology
por: Petersen, Julian, et al.
Publicado: (2023)

Molecular differences between stromal cell populations from deciduous and permanent human teeth
por: Kaukua, Nina, et al.
Publicado: (2015)

Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth
por: Dyberg, Cecilia, et al.
Publicado: (2019)

External signals regulate continuous transcriptional states in hematopoietic stem cells
por: Fast, Eva M, et al.
Publicado: (2021)

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors
por: Bedoya-Reina, O. C., et al.
Publicado: (2021)

RNA velocity of single cells
por: La Manno, Gioele, et al.
Publicado: (2018)

A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia
por: Laddach, Anna, et al.
Publicado: (2023)

Epiphyseal Cartilage Formation Involves Differential Dynamics of Various Cellular Populations During Embryogenesis
por: Zhang, Yi, et al.
Publicado: (2020)

Ablation of CNTN2+ Pyramidal Neurons During Development Results in Defects in Neocortical Size and Axonal Tract Formation
por: Kastriti, Maria Eleni, et al.
Publicado: (2019)

PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis
por: Bartesaghi, Luca, et al.
Publicado: (2019)

Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics
por: Ratz, Michael, et al.
Publicado: (2022)

Adult Prg4(+) progenitors repair long-term articular cartilage wounds in vivo
por: Massengale, Mei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6ec9h9khunl0trupnrulvguhbu