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An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering

The unique electrochemical properties of the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of b...

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Autores principales: Ritzau-Reid, Kaja I., Spicer, Christopher D., Gelmi, Amy, Grigsby, Christopher L., Ponder, James F., Bemmer, Victoria, Creamer, Adam, Vilar, Ramon, Serio, Andrea, Stevens, Molly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610826/
https://www.ncbi.nlm.nih.gov/pubmed/34035794
http://dx.doi.org/10.1002/adfm.202003710
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author Ritzau-Reid, Kaja I.
Spicer, Christopher D.
Gelmi, Amy
Grigsby, Christopher L.
Ponder, James F.
Bemmer, Victoria
Creamer, Adam
Vilar, Ramon
Serio, Andrea
Stevens, Molly M.
author_facet Ritzau-Reid, Kaja I.
Spicer, Christopher D.
Gelmi, Amy
Grigsby, Christopher L.
Ponder, James F.
Bemmer, Victoria
Creamer, Adam
Vilar, Ramon
Serio, Andrea
Stevens, Molly M.
author_sort Ritzau-Reid, Kaja I.
collection PubMed
description The unique electrochemical properties of the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4-ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end-capping strategy, into block co-polymers. By exploiting end-functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co-polymer is produced that is electroactive, processable, and bio-compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.
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spelling pubmed-76108262021-05-24 An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering Ritzau-Reid, Kaja I. Spicer, Christopher D. Gelmi, Amy Grigsby, Christopher L. Ponder, James F. Bemmer, Victoria Creamer, Adam Vilar, Ramon Serio, Andrea Stevens, Molly M. Adv Funct Mater Article The unique electrochemical properties of the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4-ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end-capping strategy, into block co-polymers. By exploiting end-functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co-polymer is produced that is electroactive, processable, and bio-compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering. 2020-08-14 /pmc/articles/PMC7610826/ /pubmed/34035794 http://dx.doi.org/10.1002/adfm.202003710 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited https://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ritzau-Reid, Kaja I.
Spicer, Christopher D.
Gelmi, Amy
Grigsby, Christopher L.
Ponder, James F.
Bemmer, Victoria
Creamer, Adam
Vilar, Ramon
Serio, Andrea
Stevens, Molly M.
An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering
title An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering
title_full An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering
title_fullStr An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering
title_full_unstemmed An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering
title_short An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering
title_sort electroactive oligo-edot platform for neural tissue engineering
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610826/
https://www.ncbi.nlm.nih.gov/pubmed/34035794
http://dx.doi.org/10.1002/adfm.202003710
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