Direct Incorporation of [(11)C]CO(2) into Asymmetric [(11)C]Carbonates

A novel carbon-11 radiolabelling methodology for the synthesis of the dialkylcarbonate functional group has been developed. The method uses cyclotron-produced short-lived [(11)C]CO(2) (half-life 20.4 min) directly from the cyclotron target in a one-pot synthesis. Alcohol in the presence of base trap...

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Detalles Bibliográficos
Autores principales: Haji Dheere, Abdul Karim, Bongarzone, Salvatore, Shakir, Dinah, Gee, Antony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610879/
https://www.ncbi.nlm.nih.gov/pubmed/34079623
http://dx.doi.org/10.1155/2018/7641304
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author Haji Dheere, Abdul Karim
Bongarzone, Salvatore
Shakir, Dinah
Gee, Antony
author_facet Haji Dheere, Abdul Karim
Bongarzone, Salvatore
Shakir, Dinah
Gee, Antony
author_sort Haji Dheere, Abdul Karim
collection PubMed
description A novel carbon-11 radiolabelling methodology for the synthesis of the dialkylcarbonate functional group has been developed. The method uses cyclotron-produced short-lived [(11)C]CO(2) (half-life 20.4 min) directly from the cyclotron target in a one-pot synthesis. Alcohol in the presence of base trapped [(11)C]CO(2) efficiently forming an [(11)C]alkylcarbonate intermediate that subsequently reacted with an alkylchloride producing the di-substituted [(11)C]carbonate (34% radiochemical yield, determined by radio-HPLC) in 5 minutes from the end of [(11)C]CO(2) cyclotron delivery.
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spelling pubmed-76108792021-06-01 Direct Incorporation of [(11)C]CO(2) into Asymmetric [(11)C]Carbonates Haji Dheere, Abdul Karim Bongarzone, Salvatore Shakir, Dinah Gee, Antony J Chem Article A novel carbon-11 radiolabelling methodology for the synthesis of the dialkylcarbonate functional group has been developed. The method uses cyclotron-produced short-lived [(11)C]CO(2) (half-life 20.4 min) directly from the cyclotron target in a one-pot synthesis. Alcohol in the presence of base trapped [(11)C]CO(2) efficiently forming an [(11)C]alkylcarbonate intermediate that subsequently reacted with an alkylchloride producing the di-substituted [(11)C]carbonate (34% radiochemical yield, determined by radio-HPLC) in 5 minutes from the end of [(11)C]CO(2) cyclotron delivery. 2018-12-10 /pmc/articles/PMC7610879/ /pubmed/34079623 http://dx.doi.org/10.1155/2018/7641304 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Haji Dheere, Abdul Karim
Bongarzone, Salvatore
Shakir, Dinah
Gee, Antony
Direct Incorporation of [(11)C]CO(2) into Asymmetric [(11)C]Carbonates
title Direct Incorporation of [(11)C]CO(2) into Asymmetric [(11)C]Carbonates
title_full Direct Incorporation of [(11)C]CO(2) into Asymmetric [(11)C]Carbonates
title_fullStr Direct Incorporation of [(11)C]CO(2) into Asymmetric [(11)C]Carbonates
title_full_unstemmed Direct Incorporation of [(11)C]CO(2) into Asymmetric [(11)C]Carbonates
title_short Direct Incorporation of [(11)C]CO(2) into Asymmetric [(11)C]Carbonates
title_sort direct incorporation of [(11)c]co(2) into asymmetric [(11)c]carbonates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610879/
https://www.ncbi.nlm.nih.gov/pubmed/34079623
http://dx.doi.org/10.1155/2018/7641304
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